WITH VITAMIN E

Quick Facts:

• Category: other
• Also Known As: Med vitamin E

Proven Benefits At A Glance:

• Vitamin E deficiency is associated with a rare genetic condition (AVED) that affects the nervous system and eyes
• High-dose vitamin E supplementation can prevent symptoms in people at genetic risk before they develop
• Early treatment may partially reverse some neurological symptoms in affected individuals
• Vitamin E supplementation can stabilize certain eye problems related to this condition

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 WITH VITAMIN E

WITH VITAMIN E

CAS Number: —

Also Known As: Med vitamin E

Category: other

WITH VITAMIN E is an other ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

The research discussed here focuses on a rare genetic condition called AVED (ataxia with vitamin E deficiency), which is inherited when a person receives two faulty copies of the TTPA gene—one from each parent. This is important context for understanding vitamin E’s role in the body. In people with AVED, vitamin E plays a critical protective role in the nervous system. When the body cannot properly manage vitamin E due to the genetic mutation, serious neurological problems can develop, typically between ages 5 and 15, including loss of muscle coordination (ataxia), clumsiness, loss of position sense, and vision changes. The research shows two key benefits of high-dose vitamin E supplementation:

#1: Prevention in at-risk individuals.

According to a 1993 peer-reviewed study, when people who carry the AVED mutation but haven’t yet developed symptoms receive lifelong high-dose vitamin E supplementation early enough—before any symptoms appear—the disease manifestations do not develop at all. This is considered targeted therapy that keeps plasma (blood) vitamin E concentrations in the high-normal range. #2: Partial reversal in symptomatic patients. The same 1993 source notes that vitamin E supplementation started early in the disease course of someone already showing symptoms “may to some extent reverse ataxia and mental deterioration,” though the language here indicates this benefit is more limited than prevention. Additionally, a 2024 Neurogenetics case series describes eye changes in two AVED patients that “remained stable under vitamin E supplementation,” suggesting the supplement can halt progression of certain vision problems associated with the condition.

It’s important to note: these findings apply specifically to people with the rare genetic AVED condition. The sources do not discuss vitamin E benefits for general skincare or other health conditions in the broader population.

💧 Skin Type Compatibility

⚠️ Don’t Combine With

🧴 Products Containing WITH VITAMIN E

• Tisserand lavender & white mint body lotion
• sunilk shampoo

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Adam MP et al. (1993). Ataxia with Vitamin E Deficiency. a peer-reviewed journal.
• Abramowicz S et al. (2024). Atypical retinopathy in ataxia with vitamin E deficiency: report of a sibship. Neurogenetics.
• Pradeep S et al. (2020). Ataxia with Vitamin E Deficiency with Predominant Cervical Dystonia. Mov Disord Clin Pract.