10309-37-2

📋 Quick facts

Description: 10309-37-2 — 10309-37-2. Formula: C18H24O. MW: 256.4. IUPAC: 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol.

Quick Facts:

• Category: other
• Also Known As: Bakuchiol

Proven Benefits At A Glance:

• Bakuchiol (10309-37-2) is a natural compound being studied for skin photoaging concerns
• Lab tests show it inhibits tyrosinase, an enzyme involved in melanin production
• Research indicates it has antioxidant properties that protect against oxidative damage
• Currently studied mainly in food preservation; human skin studies not detailed in available sources

⚗️ Chemical Overview

2,2-Bis(hydroxymethyl)propionic acid is a 3-hydroxy carboxylic acid. is used to synthesis poly(carbonate urea)urethanes; structure in first source

Source(s): ChEBI, Medical Subject Headings (MeSH), via PubChem

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Bakuchiol is attracting scientific attention as a potential treatment for photoaging—the sun damage that ages skin over time (Food Chem, 2023). Here’s what the research actually shows: #1: Tyrosinase inhibition. Tyrosinase is an enzyme that produces melanin, the pigment responsible for dark spots and uneven skin tone. In laboratory tests, bakuchiol acted as a competitive inhibitor of mushroom tyrosinase, meaning it blocks the enzyme’s active site and reduces its activity. The research measured this using real-time oxygen sensing and UV-visible light monitoring at controlled conditions (Food Chem, 2023). Notably, bakuchiol’s inhibitory potency compared favorably to kojic acid, a well-known skin-lightening ingredient, in some enzyme reactions measured.

#2: Antioxidant activity. The same study demonstrated that bakuchiol has antioxidant properties—it can neutralize harmful free radicals (reactive molecules that damage cells). This was tested through multiple laboratory oxidation models at different temperatures (Food Chem, 2023). A stoichiometric factor of 1.9 suggests bakuchiol can neutralize multiple free radical molecules efficiently. However, important limitation: these results come from controlled laboratory enzyme and chemical tests, not human skin studies. The research emphasizes bakuchiol’s potential as a natural food preservative (Food Chem, 2023), and while photoaging interest is noted, direct evidence of anti-aging benefits in human skin is not present in these abstracts.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Cariola A et al. (2023). Anti-tyrosinase and antioxidant activity of meroterpene bakuchiol from Psoralea corylifolia (L.). Food Chem.

🧴 Products Containing 10309-37-2