CANNABIS SATIVA STEM WATER

📋 Quick facts

Quick Facts:

• Category: other
• Also Known As: アサ茎水

Proven Benefits At A Glance:

• Cannabis sativa stem water is being studied for potential anti-aging benefits, specifically for protecting skin from sun damage
• Research shows fermented versions may be more effective than non-fermented ones
• The stem is an underutilized part of the plant that researchers are now investigating for skincare
• Studies focus on how the extract may help prevent collagen breakdown caused by UV radiation

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Cannabis sativa stem water is being investigated for its potential to protect skin from photoaging — the visible signs of aging like wrinkles and loss of elasticity that result from UV radiation exposure (PLoS One, 2025). Here’s how the damage typically happens: when skin is exposed to UVB rays, it creates reactive oxygen species (unstable molecules), which trigger the release of an enzyme called MMP-1 (matrix metalloproteinase-1). This enzyme breaks down collagen, the protein that keeps skin firm and elastic. UV exposure also activates signaling pathways in skin cells (ERK, JNK, and p65) that drive this aging process. In a recent study published in PLoS One (2025), researchers tested whether cannabis sativa stem water extracts could slow this process in human skin cells exposed to UVB radiation.

The key finding: #1: Fermented versions of the extract showed enhanced effectiveness — specifically 6.6% greater inhibition of MMP-1 expression compared to non-fermented extracts (PLoS One, 2025). The fermentation process, using a probiotic called Lacticaseibacillus casei, also increased flavonoid content (plant compounds with antioxidant properties) by 68.3% (PLoS One, 2025). #2: The fermented extract most effectively suppressed the UV-triggered signaling pathways and collagen breakdown in lab testing (PLoS One, 2025). It’s worth noting that previous skincare research on cannabis has typically focused on leaves or flowers; this research specifically highlights the stem as a novel source of bioactive compounds (PLoS One, 2025).

However, these findings are from laboratory studies on isolated skin cells, not human skin or clinical trials, so the real-world effectiveness and optimal concentration for consumer products remains to be established.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Kim JW et al. (2025). Enhancement of antiphotoaging properties of Cannabis sativa stem water extracts by fermentation with Lacticaseibacillus casei. PLoS One.

🧴 Products Containing CANNABIS SATIVA STEM WATER