2-AMINOBUTANOL - Skin Care Ingredients Curated By Mia Seilern

⚠️ Data is provided for informational purposes only. It may contain inaccuracies and should be independently verified. This is not medical advice. Consult a healthcare professional before making health decisions.

Description: 2-AMINOBUTANOL — BUFFERING.

All Functions: BUFFERING

Quick Facts:

Category: other
Regulatory Note: Restricted in the EU

Proven Benefits At A Glance:

2-aminobutanol is an impurity sometimes found in ethambutol drug products
A specialized analytical method can now detect it at extremely low levels
The detection method was validated to be accurate and reliable for quality control testing

Safety: CautionResearch confidence: Fair

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 2-AMINOBUTANOL

2-AMINOBUTANOL

CAS Number: 96-20-8

Also Known As: —

Category: other

EC Number: 202-488-2

Korean Name: 2-아미노부탄올

2-aminobutan-1-ol

2-AMINOBUTANOL is an other ingredient used in skincare formulations.

BUFFERING

🌍 Regulatory Status

EU: RestrictedUS: No restriction on file

EU max concentration: Maximum secondary amine content: 0.5%

📊 Comedogenicity

No data yet

Not rated for this ingredient yet.

📚 Research & Evidence

PUBMED CITATIONS

Data sources: EU CosIng PubMed

🔬 The Science

2-aminobutanol (specifically the (+) form, also called Impurity I) is a compound that can appear in ethambutol hydrochloride medications. While the available research focuses on analytical chemistry rather than skincare benefits, here’s what we know: #1: Detection capability—A novel method using reverse-phase high-performance liquid chromatography (RP-HPLC) paired with nano quantity analyte detector (NQAD) technology can now identify 2-aminobutanol at extremely small concentrations (9.8 nanograms), according to research in Biomed Chromatogr (2025). #2: Method validation—The detection technique was validated according to ICH (International Council for Harmonisation) guidelines and demonstrated to be specific, accurate, precise, linear, sensitive, and robust, making it suitable for quality control in pharmaceutical manufacturing (Biomed Chromatogr, 2025).

The research does not discuss skincare applications, topical use, or consumer benefits of 2-aminobutanol. The single available abstract is narrowly focused on pharmaceutical quality assurance rather than cosmetic or dermatological efficacy.