ACETYL HEXAPEPTIDE-3

📋 Quick facts

Description: ACETYL HEXAPEPTIDE-3 — ACETYL HEXAPEPTIDE-3. Formula: C35H62N14O11S. MW: 887.0. IUPAC: (4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]hex-5-enoic acid.

Quick Facts:

• Category: other
• Also Known As: アセチルヘキサペプチド－３

Proven Benefits At A Glance:

• Acetyl hexapeptide-3 is a bioactive peptide studied for skin benefits
• A 60-day clinical study on 24 volunteers found it may help reduce the appearance of fine lines and wrinkles
• It showed effects on skin surface texture and water retention in the outer skin layer
• Research is limited; only one small study fully supports these findings

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Acetyl hexapeptide-3 is a short chain of amino acids (the building blocks of proteins) designed to be active on skin. Here’s what the available research shows:

#1: Potential antiwrinkle effects — In a 2017 study published in the Journal of Cosmetic Dermatology, researchers gave 24 healthy volunteers either acetyl hexapeptide-3 alone, a different peptide alone, both peptides combined, or neither for 60 days. They measured skin surface texture using a device called a skin visioscan, which detects tiny ridges and valleys on skin. After 20 and 60 days, the acetyl hexapeptide-3 groups showed statistically significant improvements in these texture measurements compared to control groups—suggesting a reduction in fine surface irregularities.

The study calls this ‘antiwrinkle activity,’ though it’s important to note this measures microscopic texture changes, not visible wrinkles in the traditional sense (J Cosmet Dermatol, 2017). #2: Effects on skin hydration — The same study measured transepidermal water loss (TEWL), which is how much water evaporates from your skin’s outer layer. Higher TEWL means drier skin. Groups treated with acetyl hexapeptide-3 showed significant decreases in TEWL compared to untreated controls at both 20 and 40 days, suggesting the ingredient may help skin retain moisture better (J Cosmet Dermatol, 2017). Important limitations: This is a single, relatively small study. The research doesn’t explain how acetyl hexapeptide-3 actually works on a biological level, and results were sometimes modest in magnitude.

No additional independent studies on this specific ingredient appear in the provided sources.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Raikou V et al. (2017). The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study. J Cosmet Dermatol.

🧴 Products Containing ACETYL HEXAPEPTIDE-3