HYDROXYPROPYL TETRAHYDROPYRANTRIOL

📋 Quick facts

Description: HYDROXYPROPYL TETRAHYDROPYRANTRIOL — supports collagen and glycosaminoglycan synthesis, anti-aging (known as Pro-Xylane).

All Functions: supports collagen and glycosaminoglycan synthesis, anti-aging (known as Pro-Xylane)

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• HYDROXYPROPYL TETRAHYDROPYRANTRIOL (HPT) is a skincare ingredient studied as part of a post-laser treatment formula
• Research tested HPT paired with niacinamide after nonablative fractional laser procedures
• In lab studies, the HPT/niacinamide combination reduced inflammation and supported skin repair processes
• In a clinical trial, HPT/niacinamide showed improvements in fine lines, wrinkles, and skin roughness compared to a standard healing ointment
• The research involved participants with white and Northeast Asian skin types

⚗️ Chemical Overview

Hydroxypropyl tetrahydropyrantriol has been used in trials studying the basic science of Aging.

Source(s): DrugBank, via PubChem

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

HYDROXYPROPYL TETRAHYDROPYRANTRIOL (HPT) is a synthetic compound that has been investigated specifically in the context of post-procedure skincare. Here’s what the available research shows:

#1: Anti-inflammatory effects — In laboratory testing using cell cultures and reconstructed skin models, an HPT and niacinamide combination reduced the production of prostaglandin E2 (PGE2), which is a signaling molecule involved in inflammation (J Clin Aesthet Dermatol, 2025). This suggests the ingredient may help calm skin irritation at a cellular level. #2: Support for skin healing proteins — The same lab studies showed that HPT/niacinamide encouraged production of glycosaminoglycan (a moisture-binding molecule), alpha-smooth muscle actin (involved in skin structure), and angiogenic growth factors (which support blood vessel formation and nutrient delivery) (J Clin Aesthet Dermatol, 2025).

#3: Clinical benefits after laser treatment — In a randomized, double-blind, split-face study across multiple centers, participants received a nonablative fractional laser treatment (a type of resurfacing procedure that doesn’t remove the full thickness of skin). When HPT/niacinamide was applied twice daily for 56 days on one side of the face and compared to Aquaphor Healing Ointment on the other side, the HPT/niacinamide side showed significant improvements in fine lines, crow’s feet wrinkles, skin roughness, and overall healthy appearance (J Clin Aesthet Dermatol, 2025). Important limitation: This research specifically evaluated HPT paired with niacinamide in the context of post-laser recovery.

There is no available evidence in these sources about how HPT performs on its own, in other formulations, or for other skincare uses beyond post-procedure care.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Assier H et al. (2017). First case of contact dermatitis caused by hydroxypropyl tetrahydropyrantriol used in an anti-ageing cream. Contact Dermatitis.
• Ablon G et al. (2025). The Application of a Formulation Containing Hydroxypropyl Tetrahydropyrantriol and Niacinamide to Augment Anti-aging Benefits in a Double-blind, Randomized Nonablative Laser Treatment Study. J Clin Aesthet Dermatol.

🧴 Products Containing HYDROXYPROPYL TETRAHYDROPYRANTRIOL

• L’OREAL NORGE AS L’Oreal Revitalift Day Cream Anti Age 50ml
• Garnier Vitamin(e) C
• La roche – posay HYALU B5 Soin
• SkinCeuticals A.G.E. Interrupter Ultra Serum
• uper Multi-Corrective Anti-Aging Cream for Face and Neck
• L’OREAL NORGE AS L’Oreal Revitalift Filler Eye Cream 30ml
• Garnier,L’Oréal SkinActive Contorno Occhi Illuminante
• Kiehl’s Since 1851 Clearly Corrective Brightening Exfoliating Daily Cleanser
• L’Oréal Revitalift Laser Nuit