PUNICA GRANATUM EXTRACT

📋 Quick facts

Description: PUNICA GRANATUM EXTRACT — antioxidant (Pomegranate Extract).

All Functions: antioxidant (Pomegranate Extract)

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• Punica granatum extract is rich in polyphenolic compounds with antioxidant properties
• Research shows potential benefits for reducing wrinkles, fine lines, and improving skin radiance when taken as an oral supplement
• Topical applications may help reduce skin redness and uneven melanin
• The extract contains bioactive compounds including ellagic acid, punicic acid, and punicalagin
• Studies indicate good safety and tolerability in human trials

⚗️ Chemical Overview

See also: Carbomer (annotation moved to); Pomegranate Extract (annotation moved to); Pomegranate, ext. (annotation moved to) … View More …

Source(s): PubChem, via PubChem

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Punica granatum extract is a potent source of polyphenolic compounds—plant molecules with strong free radical scavenging activity, meaning they help neutralize unstable molecules that can damage skin (Postepy Dermatol Alergol, 2014; Food Sci Nutr, 2025). #1: Oral supplementation for visible skin improvements. In a 60-day clinical trial, a standardized pomegranate extract (300 mg daily) significantly reduced crow’s feet wrinkles, forehead fine lines, and forehead wrinkles compared to placebo (Am J Transl Res, 2024). The same study found improvements in skin radiance, tone evenness, skin moisturization, elasticity, and firmness. Notably, tyrosinase biomarker levels (an enzyme involved in melanin production) dropped by 3% in the supplemented group (Am J Transl Res, 2024).

#2: Topical skin tone and texture effects. A 12-week split-face study using a topical microemulsion formulation showed significant reductions in skin erythema (redness) and melanin levels (Postepy Dermatol Alergol, 2014). The skin lightening effects are thought to occur because ellagic acid, one of the extract’s major components, chelates copper at the active site of tyrosinase, the enzyme responsible for melanin production (Postepy Dermatol Alergol, 2014). #3: Protection against UV-induced damage. An aged pomegranate extract demonstrated high antioxidant capacity in laboratory testing and, in a 60-woman clinical trial, significantly reduced UV-induced erythema and melanin levels while improving skin hydration and lightness compared to placebo (Food Sci Nutr, 2025).

In cellular studies, the extract reduced reactive oxygen species and inflammatory cytokine levels under stress conditions (Food Sci Nutr, 2025). #4: Anti-inflammatory activity in topical formulations. Laboratory research using an ethosome gel formulation (a nanotechnology-based delivery system) showed good anti-inflammatory effects when tested on induced skin inflammation in animal models (Gels, 2022). This gel formulation achieved a 91.83% release rate of β-sitosterol, one of the extract’s bioactive compounds, suggesting effective skin penetration (Gels, 2022). #5: Safety profile. Across multiple studies—including a 60-day oral supplementation trial (Am J Transl Res, 2024), a 12-week topical trial (Postepy Dermatol Alergol, 2014), and a clinical UV protection trial (Food Sci Nutr, 2025)—no adverse effects were reported, and the extract was well tolerated by participants.

One human study also suggested radioprotective benefits for radiation-damaged skin in cancer patients, though this application is specialized (Indian J Otolaryngol Head Neck Surg, 2019).

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Alam P et al. (2022). Central Composite Design (CCD) for the Optimisation of Ethosomal Gel Formulation of Punica granatum Extract: In Vitro and In Vivo Evaluations. Gels.
• Krishnakumar A et al. (2024). Efficacy and safety of a proprietary Punica granatum extract in skin health – a randomized, placebo-controlled clinical study in healthy volunteers. Am J Transl Res.
• Parveen R et al. (2014). Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects. Postepy Dermatol Alergol.
• Ikeda Y et al. (2025). Photoprotective, Antioxidant and Anti-Inflammatory Effects of Aged Punica granatum Extract: In Vitro and In Vivo Insights. Food Sci Nutr.
• Thotambailu AM et al. (2019). Protective Effect of Punica granatum Extract in Head and Neck Cancer Patients Undergoing Radiotherapy. Indian J Otolaryngol Head Neck Surg.

🧴 Products Containing PUNICA GRANATUM EXTRACT

• 180 ml Elseve Rapid Restore
• Sally Hansen Complete Care 7-in-1 Nail Treatment
• Kirkland Moisture Conditioner
• ACURE Vivacious Volume Shampoo
• ACURE Ultra Hydrating Green Juice Cleanser
• eos 24H Moisture Shave Cream
• ACURE Brightening Cleansing Gel
• ACURE Radically Rejuvenating Cleansing Cream
• Klorane, Laboratoires Klorane, Pierre Fabre Eclat couleur : shampooing à la grenade cheveux colorés
• L’Oréal, L’Oreal Consumer products, Garnier, Fructis Fructis Shampooing fortifiant Matière & Densité
• L’Oréal, L’Oreal Consumer products, Garnier, Fructis Innovation Fructis Après-Shampooing fortifiant
• Ushuaïa Déodorant à la pulpe de grenade des Açores
• Palmolive Naturals Brilliant Color Shampoo
• L’Oréal, L’Oreal Consumer products, Garnier Shampoo bar hair food sandia
• Ushuaia Déodorant efficacité 24h Pulpe de Grenade des Açores
• Ushuaïa Gel douche hydratant à la pulpe de grenade des Açores
• Ushuaia Déodorant efficacité 24 h à la pulpe de grenade des Açores
• Ushuaia Gel douche hydratant Grenade des Açores
• Eco Cosmetics Crème Solaire Baby & Kids SPF 45
• Eco cosmetics Opalovací krém SPF 15 bio
• Urban Hydration Kiwi & Pomegranate Micellar Cleansing Water
• Ushuaïa Gel Douche Hydratant Grenade
• Acure Ultra Hydrating Shampoo
• ACURE Daily Workout Watermelon & Blood Orange Shampoo
• Carrefour, Soft Eve Contour Patches
• Garnier Hair Food Sandía
• Down Under Fruitkicks Fruitkicks Moisture & Shine