RETINAL

Description: RETINAL — retinaldehyde — anti-aging, cell turnover; more potent than retinol, gentler than tretinoin.

All Functions: retinaldehyde — anti-aging, cell turnover; more potent than retinol, gentler than tretinoin

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• The sources provided do not contain any information about retinal as a skincare ingredient
• The research abstracts discuss retinal diseases, drug delivery to the eye, medication toxicity, and caffeine’s anti-inflammatory effects in eye tissue
• None of these sources address retinal (or retinol/retinoids) for topical skincare use

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 RETINAL

RETINAL

CAS Number: 116-31-4

Also Known As: —

Category: active

EC Number: 204-135-8

Korean Name: 레틴알

2,4,6,8-Nonatetraenal, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-

RETINAL is an active ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

I cannot write this content as requested. The five research abstracts provided do not discuss retinal as a skincare ingredient at all. Instead, they cover: (1) drug delivery systems for treating retinal diseases like age-related macular degeneration and diabetic retinopathy; (2) how systemic medications can cause retinal toxicity; (3) a case study of retinal arteriovenous malformation; (4) hormonal contraceptive use and retinal vascular occlusion risk; and (5) caffeine’s anti-inflammatory effects in retinal tissue. None of these sources contain data, claims, or evidence about retinal’s effects when applied topically to skin for cosmetic or dermatological purposes. To write accurate, source-grounded consumer content about retinal as a skincare ingredient, I would need research abstracts that actually study retinal in that context—such as studies on skin penetration, effects on collagen production, photoaging reduction, or tolerability in skincare formulations.

💧 Skin Type Compatibility

⚠️ Don’t Combine With

• Benzoyl Peroxide (caution): Benzoyl peroxide oxidatively degrades retinoids when co-applied. The retinoid + BPO + light combination drove >50% degradation of tretinoin in ~2 h and ~95% in 24 h; retinaldehyde is the direct one-step precursor of retinoic acid and shares the same oxidation-prone polyene structure, so BPO blunts its efficacy. Apply at separate times of day (retinoid PM, BPO AM) or alternating days. Adapalene is the BPO-stable retinoid for same-routine combination.

🧴 Products Containing RETINAL

• lily of the desert Gel D’aloe Vera 99% – 120 ML – Lily of the Desert
• Avène, Eau Thermale Avène, Laboratoires Dermatologiques Avène, Pierre Fabre, Ysthéal Ysthéal Intense concentré antirides rénovateur de peau
• Eau Thermale Avene Eau Thermale Avéne A-Oxitive Nuit
• Verobene Verobene Radiance Melasma Cream
• Some By Mi Some By Mi Retinol Intense Reactivating Serum 50ml
• Sesderma Hydraderm Hyal C-Vit Hidraderm Hyal C-Vit

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Rowe LW et al. (2025). Beyond the injection: delivery systems reshaping retinal disease management. Expert Opin Pharmacother.
• Tsang SH et al. (2018). Drug-Induced Retinal Toxicity. Adv Exp Med Biol.
• Patel KH et al. (2017). RETINAL ARTERIOVENOUS MALFORMATION. Retin Cases Brief Rep.
• Niazi S et al. (2025). Hormonal Contraception and Retinal Vascular Occlusion Risk. Am J Ophthalmol.
• Conti F et al. (2021). Caffeine Protects Against Retinal Inflammation. Front Pharmacol.

📰 Recent News

• 9 Best Retinal Serums for Smoother, Firmer, Brighter Skin (Allure)