ROYAL JELLY EXTRACT

Description: ROYAL JELLY EXTRACT — nourishing, antioxidant (bee-derived).

All Functions: nourishing, antioxidant (bee-derived)

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• Royal jelly extract is a natural ingredient that may improve skin hydration when applied topically
• A processed form called protease-treated royal jelly showed wrinkle-reducing effects in a 12-week study on crow’s feet
• No serious side effects were reported in the available research on royal jelly skincare products
• The ingredient appears to work by affecting water retention in the outer skin layer and may influence skin thickness

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 ROYAL JELLY EXTRACT

ROYAL JELLY EXTRACT

CAS Number: 91081-56-0

Also Known As: —

Category: active

EC Number: 293-662-7

Korean Name: 로얄젤리추출물

Royal Jelly Extract is an extract obtained from royal jelly

ROYAL JELLY EXTRACT is an active ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

Royal jelly extract comes from honeybees and has been studied in two recent clinical trials for skincare benefits. Here’s what the research actually shows:

#1: Hydration boost — When people applied an essence containing royal jelly extract to their skin for 4 weeks, the water content in their stratum corneum (the skin’s outermost layer) increased significantly compared to placebo (J Cosmet Dermatol, 2022). This was tested on 35 healthy Japanese adults who reported dry skin. The study confirmed that royal jelly extract improves the skin’s ability to retain moisture, though it did not significantly change other measured factors like pore appearance or redness.

#2: Wrinkle reduction — A specially processed version called protease-treated royal jelly (pRJ) showed measurable improvements in crow’s feet wrinkles when applied as a cream for 12 weeks in a study of 70 Japanese women (J Cosmet Dermatol, 2025). Both the maximum depth and average depth of the largest wrinkle improved compared to placebo. The cream also increased dermal thickness (the layer of skin beneath the surface) and water content in the stratum corneum. #3: Possible skin microbiome effects — The protease-treated version showed decreased bacterial microbiome changes on cheek skin, though the significance of this for overall skin health isn’t explained in the available research (J Cosmet Dermatol, 2025).

#4: Stem cell activity — In laboratory testing, protease-treated royal jelly increased expression of a marker associated with epidermal stem cell function (J Cosmet Dermatol, 2025). However, the sources acknowledge this is the first clinical trial demonstrating wrinkle benefits, so this is relatively new territory. Safety: Neither study reported adverse events during the study periods, and the products were considered highly safe (J Cosmet Dermatol, 2022; 2025). Limitations: Both studies were conducted on Japanese populations and used the split-face method (applying product to one side of the face). Larger studies on diverse populations would strengthen confidence in these findings.

💧 Skin Type Compatibility

⚠️ Don’t Combine With

🧴 Products Containing ROYAL JELLY EXTRACT

• RETINOL RETINOL SKIN CREAM
• Monte dos bens Creme para mãos
• Le Petit Marseillais Shampooing au lait d’avoine et à la gelée royale
• L’Oréal, L’Oreal Consumer products, L’Oréal Paris, Elseve Elseve Re-Nutrition Soin-crème nourrissant
• Maybelline Affinitone 30 Sand Beige
• L’Oréal, L’Oreal Consumer products, Garnier, Ultra doux Ultra doux Corps – Beurre réparateur Trésors de Miel
• L’Oréal, L’Oreal Consumer products, Garnier, Ultra Doux Ultra Doux Lèvres Baume à lèvres nourrissant Trésors de Miel
• Vanedo Royal Jelly Essence Mask
• Tío Nacho Shampoo Herbolaria Milenaria
• Rimmel Baume à lèvres 040 rose blush

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Ikegami S et al. (2025). Effect of Protease-Treated Royal Jelly Extract on Facial Wrinkles: A Placebo-Controlled, Double-Blind, Parallel-Group Study. J Cosmet Dermatol.
• Maeda Y et al. (2022). Effect of facial application of essence containing royal jelly extract on stratum corneum moisture content: A placebo-controlled, double-blind, parallel-group study. J Cosmet Dermatol.