VITIS VINIFERA SEED EXTRACT

📋 Quick facts

Description: VITIS VINIFERA SEED EXTRACT — antioxidant (Grape Seed Extract).

All Functions: antioxidant (Grape Seed Extract)

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• Vitis vinifera seed extract (VVSE) is a plant-based ingredient studied for supporting vein health
• Research shows it may help reduce venous reflux time—a measure of blood flow problems in the legs—when taken as an oral supplement
• In a 12-week clinical trial, people taking VVSE plus lifestyle changes saw better results than lifestyle changes alone
• Study participants reported improvements in leg symptoms and quality of life with VVSE supplementation
• Effects were seen in both superficial veins (closer to the skin) and deeper leg veins

⚗️ Chemical Overview

See also: Grape Seed Extract (annotation moved to); Grape, red, ext. (annotation moved to); Grape, red, extract (annotation moved to) … View More …

Source(s): PubChem, via PubChem

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Vitis vinifera seed extract comes from grapevine seeds and has been investigated for its potential effects on venous insufficiency—a condition where veins struggle to efficiently return blood from the legs to the heart, sometimes causing varicose veins. #1: The primary finding is that oral VVSE may reduce venous reflux time, which is measured using Doppler ultrasound to detect how long blood flows backward in veins instead of moving toward the heart (J Vasc Surg Venous Lymphat Disord). In the clinical trial, participants took 150 mg of VVSE twice daily for 12 weeks alongside therapeutic lifestyle changes. The VVSE group experienced significantly greater reductions in mean venous reflux time compared to the control group, which only received lifestyle modifications.

#2: Improvements were documented in specific veins, with notable effects observed in the great saphenous vein (the longest vein in the leg) and the popliteal vein (behind the knee), affecting both superficial and deep leg veins (J Vasc Surg Venous Lymphat Disord). A higher proportion of VVSE users achieved clinically improved reflux measurements—defined as reflux time dropping to ≤0.5 seconds in superficial veins or ≤1 second in deep veins—compared to the lifestyle-only group. #3: Beyond the technical venous measurements, VVSE supplementation was associated with superior symptom improvement, including greater reductions in the Venous Clinical Severity Score (a medical assessment of vein-related symptoms) and the Chronic Venous Insufficiency Quality of Life Questionnaire score, suggesting participants reported feeling better (J Vasc Surg Venous Lymphat Disord).

The beneficial effects remained consistent across diverse patient subgroups and were particularly notable in people with deep venous insufficiency.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Bae S et al. (2026). Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial. J Vasc Surg Venous Lymphat Disord.

🧴 Products Containing VITIS VINIFERA SEED EXTRACT

• CD, Lomamead Frische Deo 24h Granatapfel
• Pantene Tratamiento reparador de keratina bambú
• Splat Global LLC Innova Sensitive
• TIS Lipstick propolis
• Herbal Essence pure Potent Aloe Bamboo