2-AMINO-4-HYDROXYETHYLAMINOANISOLE SULFATE

📚 Research & Evidence

🔬 The Science

2-Amino-4-hydroxyethylaminoanisole sulfate is a chemical compound that functions as a coupler in oxidative hair dyes—that means it works alongside other chemicals to help create the final hair color during the dyeing process (Int J Toxicol, 2013). The Cosmetic Ingredient Review Expert Panel, after evaluating animal and human safety data, concluded that #1: this ingredient is safe for use in oxidative hair dye formulations (Int J Toxicol, 2013). However, there is one important caveat: #2: the ingredient should not be used in cosmetic products where N-nitroso compounds—potentially harmful chemicals—may form during storage or use (Int J Toxicol, 2013). While approved for safety, it is worth noting that #3: allergic contact dermatitis (a type of allergic skin reaction) from permanent hair dyes is common overall, and this particular ingredient has been identified as a rare contact allergen (Contact Dermatitis, 2016).

In a study of 902 dermatitis patients patch tested with this ingredient between 2005 and 2014, #4: 1.4% showed positive allergic reactions, making it an uncommon but real concern for sensitive individuals (Contact Dermatitis, 2016). The research did not indicate that the ingredient caused irritant reactions in these patients—only allergic ones (Contact Dermatitis, 2016).

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Burnett CL et al. (2013). Safety assessment of 2-amino-4-hydroxyethylaminoanisole and 2-amino-4-hydroxyethylaminoanisole sulfate as used in cosmetics. Int J Toxicol.
• Madsen JT et al. (2016). 2-Amino-4-hydroxyethylaminoanisole sulfate – a coupler causing contact allergy from use in hair dyes. Contact Dermatitis.

🧴 Products Containing 2-AMINO-4-HYDROXYETHYLAMINOANISOLE SULFATE

• Henkel, Schwarzkopf Natural & Easy 545 blond cendré
• CONAXESS TRADE NORGE AS Blonde Blondering 10.1
• Henkel, Palette, Schwarzkopf Palette Salon Colors 4.89
• Llongueras Color Advance negro nº1
• hair colour
• Les 3 Chênes Color & Soin 5G Light Golden
• Chantal Crème colorante permanente Color Variété Brun Noix
• CONAXESS TRADE NORGE AS Live Urban Metallics U71 Metallic Silver
• henkel, schwarzkopf Kit Racines Noir R5
• Conaxess trade norway Natural & Easy 564 Lysbrun
• Conaxess trade norway Natural & Easy 570 Mellombrun
• Conaxess trade norway Natural & Easy 580 Mørkbrun