4-AMINO-3-HYDROXYBUTYRIC ACID

📋 Quick facts

Description: 4-AMINO-3-HYDROXYBUTYRIC ACID — SKIN CONDITIONING.

All Functions: SKIN CONDITIONING

Quick Facts:

• Category: emollient

Proven Benefits At A Glance:

• 4-amino-3-hydroxybutyric acid (GABOB) is a synthetic compound that can be manufactured through chemical synthesis
• The ingredient can be reliably measured and identified in skincare products using laboratory testing methods
• Limited publicly available research on skin health or cosmetic applications exists in the provided sources

⚗️ Chemical Overview

Gamma-amino-beta-hydroxybutyric acid is a gamma-amino acid comprising 4-aminobutyric acid having a 2-hydroxy substituent. It is a gamma-amino acid and a 3-hydroxy monocarboxylic acid. It is functionally related to a butyric acid. It is a conjugate acid of a 4-amino-3-hydroxybutanoate. It is a tautomer of a gamma-amino-beta-hydroxybutyric acid zwitterion. γ-amino-β-hydroxybutyric acid has been reported in Homo sapiens with data available. RN given refers to cpd without isomeric designation

Source(s): ChEBI, Medical Subject Headings (MeSH), LOTUS – the natural products occurrence database, via PubChem

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

4-amino-3-hydroxybutyric acid, commonly abbreviated as GABOB, is a synthetically manufactured amino acid derivative. According to the Journal of Pharmaceutical Sciences (1978), the compound can be produced through a three-step chemical synthesis starting from crotonic acid, involving bromination and conversion with ammonium hydroxide, then refluxing in acidic water to yield the final product in good quantities. From a quality-control perspective, the Journal of Chromatography A (2000) established that GABOB can be reliably identified and measured in finished pharmaceutical products using reversed-phase liquid chromatography—a standard laboratory technique that detects the compound at UV wavelength 210 nm. The testing method demonstrated excellent accuracy (100.1%) and very low measurement variability (0.68% relative standard deviation), meaning manufacturers can verify the ingredient’s presence and concentration in products with high precision.

It’s important to note: the research abstracts provided focus on the chemical synthesis and analytical testing of GABOB. Neither source contains information about skin benefits, skincare applications, or how this ingredient might affect skin health. Any claims about cosmetic or dermatological benefits would require additional research not present in these sources.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Pinza M et al. (1978). Convenient synthesis of (RS)-4-amino-3-hydroxybutyric acid. J Pharm Sci.
• Candela M et al. (2000). Validation of an analysis method for 4-amino-3-hydroxybutyric acid by reversed-phase liquid chromatography. J Chromatogr A.

🧴 Products Containing 4-AMINO-3-HYDROXYBUTYRIC ACID