ACETYL DIPEPTIDE-1 CETYL ESTER

📋 Quick facts

Description: ACETYL DIPEPTIDE-1 CETYL ESTER — HAIR CONDITIONING, SKIN CONDITIONING.

All Functions: HAIR CONDITIONING, SKIN CONDITIONING

Quick Facts:

• Category: emollient

Proven Benefits At A Glance:

• Acetyl dipeptide-1 cetyl ester is a skin-soothing ingredient tested in a clinical study on sensitive skin
• In a head-to-head comparison, it helped calm capsaicin-induced burning (a standard sensitivity test) within 15 minutes
• It worked more slowly than a comparison ingredient in the first 1–2 minutes, but showed similar overall calming effects

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Acetyl dipeptide-1 cetyl ester is a synthetic compound created by combining amino acids (the building blocks of proteins) with a fatty chain. In this case, the ingredient was tested as part of a skincare product on people with self-reported sensitive skin. Researchers used a controlled test where they applied capsaicin—a compound that creates a burning sensation—to the skin, then measured how well the product reduced that discomfort (J Eur Acad Dermatol Venereol, 2016). #1: The ingredient demonstrated a calming effect on capsaicin-induced burning sensations, with all 31 study participants showing reduced stinging within the 15-minute observation window (J Eur Acad Dermatol Venereol, 2016).

However, the research showed a nuance worth noting: #2: When compared directly to another soothing ingredient (4-t-butylcyclohexanol), acetyl dipeptide-1 cetyl ester worked more slowly in the very early stages—the comparison ingredient reduced burning more noticeably at the 1- and 2-minute marks (J Eur Acad Dermatol Venereol, 2016). #3: By the time of peak burning intensity and over the full 15-minute period, both ingredients performed similarly, suggesting acetyl dipeptide-1 cetyl ester caught up and maintained comparable comfort benefits (J Eur Acad Dermatol Venereol, 2016). This was a single small study, so more research would help clarify how this ingredient performs in different formulations and skin types.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Schoelermann AM et al. (2016). Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin. J Eur Acad Dermatol Venereol.

🧴 Products Containing ACETYL DIPEPTIDE-1 CETYL ESTER

• anti-blemish keratolytic emulsion
• StriVectin TL Advanced Tightening Neck Cream PLUS
• La Roche-Posay Toleriane Ultra – Peaux ultra sensibles ou allergiques
• Bioderma Cicabio crème
• Bioderma Cicabio spf 50+
• Caudalie Baume liftant regard Resveratrol [Lift]
• Caudalie Sérum fermeté Resveratrol [Lift]
• Laab MEN Multi-Booster Ultralekki krem nawilżająco-kojący
• Mixa Crème anti réactions