HYDROLYZED HYALURONIC ACID

Description: HYDROLYZED HYALURONIC ACID — hydration, smaller molecular weight than hyaluronic acid for enhanced penetration.

All Functions: hydration, smaller molecular weight than hyaluronic acid for enhanced penetration

Quick Facts:

• Category: humectant

Proven Benefits At A Glance:

• Hydrolyzed hyaluronic acid can be engineered into very fine microneedles for skincare and pharmaceutical delivery
• These microneedles are extremely small—about 24 micrometers tall (roughly 1/4 the width of a human hair)
• The ingredient can be formulated with high water content while maintaining the structure needed for delivery systems
• This technology is still in development and represents a new manufacturing approach

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 HYDROLYZED HYALURONIC ACID

HYDROLYZED HYALURONIC ACID

CAS Number: –

Also Known As: —

Category: humectant

EC Number: –

Korean Name: 하이드롤라이즈드하이알루로닉애씨드

Hydrolyzed Hyaluronic Acid is the hydrolysate of Hyaluronic Acid derived by acid, enzyme or other method of hydrolysis

HYDROLYZED HYALURONIC ACID is a humectant ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

Hydrolyzed hyaluronic acid is a form of hyaluronic acid that has been broken down into smaller molecular pieces through a process called hydrolysis. According to research published in *Gels* (2022), this ingredient can be transformed into extremely fine microneedles—tiny spike-like structures measuring about 24 micrometers in height and 13 micrometers in diameter. To put that in perspective, a human hair is roughly 70 micrometers wide, so these needles are incredibly small. The breakthrough described in the *Gels* study involves #1: manufacturing these microneedles using water-permeable molds rather than traditional solid molds, which allows the hydrolyzed hyaluronic acid to retain up to 67% water content during the fabrication process.

This is significant because it maintains the ingredient’s fluidity and workability while creating precise, uniform structures. The researchers suggest this opens possibilities for #2: delivering various cosmetic and pharmaceutical materials through these microneedle systems. It’s important to note that this research focuses on the *manufacturing technology* for microneedles rather than clinical efficacy in skincare. The sources provided do not contain data on how effective these microneedles are at delivering benefits to skin, how long results last, or how they compare to other delivery methods.

💧 Skin Type Compatibility

Derived from this ingredient’s irritancy potential and comedogenicity rating against the needs of each skin type — e.g. oily and acne-prone skin are marked down for pore-clogging ingredients, sensitive skin for irritants. A starting heuristic, not a dermatological verdict.

⚠️ Don’t Combine With

🧴 Products Containing HYDROLYZED HYALURONIC ACID

• BCL Kansosan Skincare Moisture Base AQ
• Somatoline Latte Detergente Viso e Occhi
• Neutrogena Gel de Limpeza Facial Neutrogena Hydro Boost
• Johnson & Johnson, Neutrogena, Santé Beauté France Deep Clean
• Labcare, Labcare cosmetics Crema viso anti-age
• Garnier Vitamin(e) C
• Neutrogena Hydro Boost
• Neutrogena Hydro Boost Water Gel Lotion SPF 50
• CeraVe CeraVe Daily Moisturizing Lotion
• Unilever, Nexxus Prep & Protect Leave-in Spray
• StriVectin TL Advanced Tightening Neck Cream PLUS
• CeraVe CeraVe Foaming Facial Cleanser
• Caudalie PREMIER CRU LA CRÈME
• N.A.E., Naturale Antica Erboristeria crème nuit anti-âge bio
• Laroche-posay HYALU B5 Sérum
• Vichy LIFTACTIV Vitamine C avec de l’acide hyaluronique
• La roche – posay HYALU B5 Soin
• EAU THERMALE JONZAC Reactive CONTROL, Crème miraculeuse HAUTE TOLERANCE
• Caudalie Baume liftant regard Resveratrol [Lift]
• Caudalie Sérum fermeté Resveratrol [Lift]

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Miura S et al. (2022). Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold. Gels.