HYDROLYZED COLLAGEN

Description: HYDROLYZED COLLAGEN — hydration, temporary plumping (sits on skin surface rather than penetrating).

All Functions: hydration, temporary plumping (sits on skin surface rather than penetrating)

Quick Facts:

• Category: humectant

Proven Benefits At A Glance:

• Hydrolyzed collagen is a small peptide made by breaking down collagen from animal or marine sources
• Multiple studies show it may improve skin hydration and elasticity when taken as an oral supplement for 12 weeks
• Research suggests it might help reduce the appearance of wrinkles
• One study found it didn’t help with severe skin thinning in older women
• A supplement combining hydrolyzed collagen with amino acids showed promise for hair loss when used alongside medical treatment

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 HYDROLYZED COLLAGEN

HYDROLYZED COLLAGEN

CAS Number: 92113-31-0 / 73049-73-7

Also Known As: —

Category: humectant

EC Number: 295-635-5 / –

Korean Name: 하이드롤라이즈드콜라겐

Collagens, hydrolyzates. Substance obtained by acidic, alkaline, or enzymatic hydrolysis of hoofs and horns composed primarily of amino acids, peptides, and proteins. It may contain impurities consisting chiefly of carbohydrates and lipids along with smaller quantities of miscellaneous organic substances of biological origin.

HYDROLYZED COLLAGEN is a humectant ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

Hydrolyzed collagen (HC) is a processed form of collagen made by breaking down the protein using enzymes in specific conditions (Molecules, 2019). The result is small peptide chains, typically 3-6 KDa in molecular weight. These peptides can be sourced from bovine, porcine, or marine origins like fish skin and bones, with marine sources showing promising properties in recent research (Molecules, 2019). When taken as an oral supplement, hydrolyzed collagen appears to have measurable effects on skin aging markers. A meta-analysis of 19 clinical trials involving 1,125 participants aged 20-70 years found that #1: hydrolyzed collagen supplementation improved skin hydration compared to placebo, #2: increased skin elasticity, and #3: reduced the appearance of wrinkles (Int J Dermatol, 2021).

A separate meta-analysis of 14 studies with 967 participants confirmed these findings, specifically showing that a 12-week supplementation regimen enhanced skin moisture and elasticity (Cureus, 2023). Both reviews noted these benefits held up in subgroup analyses. However, results aren’t universally positive. A 6-month double-blind study of 56 postmenopausal women with advanced skin thinning (dermatoporosis) found no significant improvement in skin elasticity, thickness, or appearance whether hydrolyzed collagen was taken orally (5g daily), applied topically (2.5% serum), or both (Dermatol Ther, 2023). The researchers concluded it should not be used routinely for this condition. Beyond skin, one controlled trial tested a supplement combining hydrolyzed fish-origin collagen (300mg per dose) with amino acids and minerals in 83 people with hair loss.

When this supplement was added to standard medical hair loss treatments for 12 weeks, it showed improvements compared to medication alone (Skin Res Technol, 2023)—though this formulation contained multiple active ingredients, so hydrolyzed collagen’s individual contribution isn’t entirely clear.

💧 Skin Type Compatibility

⚠️ Don’t Combine With

🧴 Products Containing HYDROLYZED COLLAGEN

• RETINOL RETINOL SKIN CREAM
• levia collagen and milk body lotion
• Eveline Cosmetics Cooling compress hydrogel eye pads
• Piel renovada crema corporal
• savia
• Idraet Pro Reti-C Retinol & Vitamin C
• thick & full biotin & collagen shampoo
• Carrefour Gel de baño leche
• Agrado Agrado champu profesional
• Light irridiance Macadamia spirit
• Linea Verde Champu balsamico uso frecuente
• Inibsa,Perrigo Gel dermatológico
• Deliplus Crema solar
• SB Mask with glitter
• OGX Thick & Full Biotin & Collagen Conditioner
• Hask Keratin Protein
• rael beauty collagen plump and smooth facial sheet masks
• It Cosmetics Confidence In A Cream Anti-Aging Moisturizer
• Cantu Cantu Shea Butter Leave In Conditioning Repair Cream
• mask skin technology

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• de Miranda RB et al. (2021). Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol.
• León-López A et al. (2019). Hydrolyzed Collagen-Sources and Applications. Molecules.
• Dewi DAR et al. (2023). Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis. Cureus.
• Milani M et al. (2023). Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair loss (androgenetic alopecia, AGA or FAGA or telogen effluvium). A prospective, randomized, 3-month, controlled, assessor-blinded study. Skin Res Technol.
• Guadanhim LRS et al. (2023). Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study. Dermatol Ther (Heidelb).