MYRISTOYL PENTAPEPTIDE-17

📋 Quick facts

Description: MYRISTOYL PENTAPEPTIDE-17 — peptide, skin conditioning, anti-aging.

All Functions: peptide, skin conditioning, anti-aging

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• MYRISTOYL PENTAPEPTIDE-17 is a synthetic peptide containing a myristoyl group, a type of fatty acid attachment studied in cellular biology
• Research on myristoylation (the process this ingredient relates to) focuses primarily on brain function, cardiovascular health, and cancer biology—not skincare
• The available research does not include studies on this ingredient’s effects on skin health, aging, or topical application
• Most research involves internal cellular processes, not topical skincare use

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Myristoylation is a cellular process where a fatty acid called myristic acid is attached to proteins, allowing them to function properly. The sources describe this as a post-translational modification—meaning it happens after a protein is made. Two enzymes called NMT1 and NMT2 (N-myristoyltransferases) perform this attachment in human cells (J Transl Med, 2024). The research explores myristoylation’s role in several biological systems: #1: In the brain, myristoylation of synaptic proteins appears important for memory formation and learning. When researchers blocked this process in mouse neurons, learning-dependent changes in key proteins like NMDA receptors were prevented (EMBO J, 2025). #2: In blood vessels, myristoylation affects a protein called ATF2, which influences endothelial barrier integrity—the protective lining of blood vessels.

This pathway may be relevant to cardiovascular disease (Adv Sci (Weinh), 2025). #3: In nerve cells, myristoylation of a protein called FSP1 appears to protect against ferroptosis, a type of cell death linked to neurodegeneration (Redox Biol, 2024). #4: In cancer research, blocking myristoylation has shown potential as a treatment strategy because some cancer cells depend heavily on NMT enzymes (J Transl Med, 2024). Critically, none of these sources examine topical application of MYRISTOYL PENTAPEPTIDE-17 to skin, skin barrier function, wrinkles, hydration, or any conventional skincare endpoint. The research describes fundamental cellular and neurological processes, not cosmetic or dermatological effects.

Without skincare-specific research, no claims about skin benefits can be made from these sources.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Rajala RV et al. (2000). N-myristoyltransferase. Mol Cell Biochem.
• Matthews B et al. (2025). Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors. EMBO J.
• Feng R et al. (2025). SIRT6 Lysine-Demyristoylates ATF2 to Ameliorate Vascular Injury via PRKCD/VE-Cadherin Pathway Regulating Vascular Endothelial Barrier. Adv Sci (Weinh).
• Liu N et al. (2024). Regulation of FSP1 myristoylation by NADPH: A novel mechanism for ferroptosis inhibition. Redox Biol.
• Beauchamp E et al. (2024). Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition. J Transl Med.

🧴 Products Containing MYRISTOYL PENTAPEPTIDE-17

• Sally Hansen Complete Care 7-in-1 Nail Treatment
• ILIA Beauty Limitless Lash Mascara