PYRIDOXINE

Description: PYRIDOXINE — vitamin B6, skin conditioning.

All Functions: vitamin B6, skin conditioning

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• Pyridoxine is vitamin B6, a form that plays a role in maintaining healthy skin function
• Research shows pyridoxine may increase filaggrin production in skin cells, which is relevant to skin barrier health
• In combination with cysteine and ascorbic acid, pyridoxine may support glutathione production in skin
• High-dose pyridoxine in oral medications has been reported to trigger rosacea-like skin reactions in some cases
• Chemotherapy-related hand-foot syndrome: evidence that pyridoxine prevents this condition is insufficient, though there may be a modest tendency toward reduction

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 PYRIDOXINE

PYRIDOXINE

CAS Number: 65-23-6 / 8059-24-3

Also Known As: —

Category: active

EC Number: 200-603-0 / 232-503-8

Korean Name: 피리독신

3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-; vitamine B6

PYRIDOXINE is an active ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

Pyridoxine (vitamin B6) is one of several forms of vitamin B6, and its role in skin health is an emerging area of research. Here’s what the current evidence shows:

#1: Skin barrier and filaggrin: According to research in Molecular Biology Reports (2021), pyridoxine appears to increase expression of profilaggrin mRNA and boost filaggrin protein production in a dose-dependent manner in normal human skin cells (keratinocytes). Filaggrin is a structural protein critical to the skin barrier—deficiency is linked to conditions like atopic dermatitis. The mechanism appears to involve P2X purinoceptor signaling. While this laboratory finding is promising, it represents early-stage research and hasn’t yet been confirmed in human skin studies.

#2: Antioxidant support in combination: A 2024 study in the Journal of Nutritional Science and Vitaminology examined pyridoxine combined with cysteine and ascorbic acid (vitamin C). In both cultured skin cells and 3D human skin models, this combination increased glutathione synthesis—an important cellular antioxidant. The effect was further enhanced when alpha-lipoic acid was added. This suggests pyridoxine may contribute to skin cells’ ability to manage oxidative stress, though these results come from laboratory models, not human clinical trials. #3: Potential adverse reactions: A case study published in Acta Clinica Croatica (2015) documented a 53-year-old woman who developed rosacea-like dermatitis (facial redness and visible blood vessels) while taking a fixed combination of isoniazid and pyridoxine for tuberculosis treatment.

This suggests very high oral doses of pyridoxine, particularly in combination with other medications, may potentially trigger skin inflammation in susceptible individuals—though this appears to be rare. #4: Chemotherapy side effect prevention: A 2021 meta-analysis in Clinical and Experimental Dermatology pooled data from 14 studies (1,570 patients) examining whether pyridoxine could prevent hand-foot syndrome, a skin toxicity from chemotherapy. The analysis found no statistically significant difference between pyridoxine and control groups. However, researchers noted pyridoxine “might have a tendency” toward modest reduction—meaning the evidence is currently insufficient to recommend it for this purpose. Limitations: Most evidence comes from laboratory studies or medical applications (tuberculosis, chemotherapy) rather than cosmetic skincare use.

Human clinical trials specifically testing pyridoxine in topical or oral skincare formulations for non-medical populations are limited in these sources.

💧 Skin Type Compatibility

⚠️ Don’t Combine With

🧴 Products Containing PYRIDOXINE

• sebamed Flüssig-Wasch-Emulsion
• Nacomï White Black Face Mask
• Carrefour Soin de jour hydratant fondant
• Glow and lovely
• Bonpreu Xampu familiar bon preu
• garnier fructis sleek and shine
• Pilexil,Lacer Pilexil
• Fructis Aloe Hydro Bomb Kräftigendes Shampoo
• l-oreal, l-oreal-consumer-products, garnier Fructis Aloe Hydra Bomb
• studio line clean gel
• REMEDY CALAZIME Skin Protectant Paste
• Spring Valley Women’s Multi With Fruits & Vegetables
• Garnier fructis shampoo
• Garnier Fructis Shampoo Grow Strong
• Garnier Fructis Shampoo
• petal fresh superfoods smooth operator shampoo
• FILORGA TIME-FILLER Crème Absolue Correction Rides
• Hairlust Hair Formula Gummies for Women
• Henkel, Schwarzkopf Kératine Color 4.6 Châtain Chocolat
• Henkel, Schwarzkopf Kératine Color Châtain Clair Subtil 6.0

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Rezaković S et al. (2015). Pyridoxine induced rosacea-like dermatitis. Acta Clin Croat.
• Lian S et al. (2021). Pyridoxine for prevention of hand-foot syndrome caused by chemotherapy agents: a meta-analysis. Clin Exp Dermatol.
• Shtyrlin NV et al. (2020). Novel Bis-Ammonium Salts of Pyridoxine: Synthesis and Antimicrobial Properties. Molecules.
• Fujishiro M et al. (2021). Pyridoxine stimulates filaggrin production in human epidermal keratinocytes. Mol Biol Rep.
• Nomura N et al. (2024). Cooperation of Cysteine, Ascorbic Acid, Pyridoxine, and α-Lipoic Acid in Antioxidant Effects on Human Keratinocytes and 3D Human Skin Models. J Nutr Sci Vitaminol (Tokyo).