PALMITOYL HEXAPEPTIDE-12

Description: PALMITOYL HEXAPEPTIDE-12 — peptide, anti-aging, supports skin firmness.

All Functions: peptide, anti-aging, supports skin firmness

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• Palmitoyl hexapeptide-12 is a self-assembling peptide (SAP) studied for anti-aging properties
• Research shows it can penetrate into multiple layers of skin (stratum corneum and epidermis)
• The peptide appears to form gel structures within skin using the skin’s own ions
• Studies suggest it may help strengthen and repair the skin barrier
• Limited research exists; most data comes from one recent 2025 study using specialized lab techniques

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 PALMITOYL HEXAPEPTIDE-12

PALMITOYL HEXAPEPTIDE-12

CAS Number: 171263-26-6

Also Known As: —

Category: active

EC Number: –

Korean Name: 팔미토일헥사펩타이드-12

Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-

PALMITOYL HEXAPEPTIDE-12 is an active ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

Palmitoyl hexapeptide-12 belongs to a category called self-assembling peptides (SAPs)—short chains of amino acids (the building blocks of proteins) that can organize themselves into structured forms when they encounter the right environment. This particular peptide has a palmitoyl group attached, which is a fatty acid chain that helps it interact with skin. #1: The peptide can penetrate skin’s outer layers. According to research in ACS Applied Bio Materials (2025), palmitoyl hexapeptide-12 is able to move through both the stratum corneum (the skin’s outermost dead cell layer) and into the epidermis (the living cell layer beneath it). #2: It forms gel structures in skin.

The same study found that the peptide transitions from a liquid (sol) form to a gel form once inside the skin, using ions naturally present in skin tissue to trigger this transformation. #3: It may strengthen a compromised barrier. After the skin barrier was artificially weakened in the lab (through delipidation—removal of fats), palmitoyl hexapeptide-12 demonstrated an ability to restore mechanical strength and repair, measured through advanced techniques like stimulated Raman scattering. #4: It works cooperatively with native skin molecules. Research showed the peptide can co-assemble with the skin’s own structural molecules, suggesting it integrates with existing skin architecture rather than simply sitting on the surface.

However, important caveats apply: the research is limited to one recent study using specialized laboratory and ex vivo (removed tissue) methods. Short-term effects on living human skin were measured, but long-term benefits, optimal concentrations, and real-world efficacy in finished products remain unclear.

💧 Skin Type Compatibility

⚠️ Don’t Combine With

🧴 Products Containing PALMITOYL HEXAPEPTIDE-12

• Clinique Fresh Pressed 7-Day System with Pure Vitamin C
• Palmer’s Crema para el busto
• Clinique Clinique For Men Anti-Age Eye Cream 15 ml
• Gold Bond Ultimate Eczema Relief Skin Protectant Cream
• Gold Bond Diabetics’ Dry Skin Relief Foot Cream
• Three sisters cafe GOLD BOND ULTIMATE healing hand cream Net wt 3 oz (85 9)
• Clinique Clinique Moisture Surge 100H Auto-Replenishing Hydrator 75 ml
• clinique anit age mpisturizer
• Guerlain Crème jour – Abeille Royale
• Guerlain Abeille Royale Huile-en-eau Jeunesse
• gold bond gold bond ultimate eczema relief
• Clinique Clinique Smart Clinical Repair Wrinkle Correcting Eye Cream 15 ml

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Ligorio C et al. (2025). Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits. ACS Appl Bio Mater.