ACETYL TETRAPEPTIDE-5

📋 Quick facts

Description: ACETYL TETRAPEPTIDE-5 — peptide, reduces appearance of under-eye puffiness.

All Functions: peptide, reduces appearance of under-eye puffiness

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• Acetyl tetrapeptide-5 is a bioactive peptide used in cosmetics for potential anti-aging benefits
• Research tested it at 100 μg/mL concentration for specific enzyme activity
• It was studied as part of multi-peptide formulas rather than alone
• A combination formula containing acetyl tetrapeptide-5 showed protective effects in lab tests on human skin cells

⚗️ Chemical Overview

See also: Acetyl octapeptide-3; acetyl tetrapeptide-5 (component of).

Source(s): PubChem, via PubChem

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Acetyl tetrapeptide-5 is a short chain of amino acids (peptides are small protein fragments) that researchers have investigated for anti-aging potential. According to *Skin Pharmacology and Physiology* (2021), the ingredient was tested at an optimal concentration of 100 μg/mL for its ability to influence angiotensin-converting enzyme 1 activity—a process potentially relevant to skin aging. However, the published research didn’t examine acetyl tetrapeptide-5 in isolation. Instead, #1: it was studied as part of a four-peptide mixture (combined with carnosine, hexapeptide-11, and acetyl hexapeptide-3) that showed promise in lab tests. When human skin cells (fibroblasts) were exposed to hydrogen peroxide—a stress that mimics premature aging—the peptide mixture #2: reduced harmful molecules like malondialdehyde and free radicals, and #3: increased levels of hydroxyproline and elastin, while boosting antioxidant enzyme activity.

The source notes that bioactive peptides in general have ‘protective effects on skin and efficient absorption,’ but emphasizes that different peptide combinations need proper testing since they can produce synergistic (additive) or antagonistic (opposing) effects. The available research is limited to this one controlled laboratory study, so real-world benefits in finished skincare products remain unclear.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Wu Y et al. (2021). Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts. Skin Pharmacol Physiol.

🧴 Products Containing ACETYL TETRAPEPTIDE-5

• Cien Roll-on Ojos
• collagen peptide