PALMITOYL OLIGOPEPTIDE

Description: PALMITOYL OLIGOPEPTIDE — peptide, supports collagen production, anti-aging.

All Functions: peptide, supports collagen production, anti-aging

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• PALMITOYL OLIGOPEPTIDE is a modified peptide that includes palmitoylation, a type of chemical modification
• Research shows a related compound (palmitoyl-RGD) may support skin structure by boosting production of laminin and collagen at the dermal-epidermal junction
• Palmitoylation is a biochemical process that affects protein function, localization, and stability in cells
• Limited direct human data exists; most evidence comes from laboratory studies on skin cells

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 PALMITOYL OLIGOPEPTIDE

PALMITOYL OLIGOPEPTIDE

CAS Number: —

Also Known As: —

Category: active

Korean Name: 팔미토일올리고펩타이드

Palmitoyl Oligopeptide (Retired) is the product obtained by the reaction of palmitic acid with either a tripeptide consisting of gly-his-lys, or a hexapeptide consisting of val-gly-val-ala-pro-gly.

The INCI Name, Palmitoyl Oligopeptide, originally developed in 1994, was designated with a retired status in 2013. For an interim period of time, trade name assignments formerly published with the name Palmitoyl Oligopeptide will be retained in the retired monograph, and also published with the new name assignments which are either Palmitoyl Tripeptide-1 or Palmitoyl Hexapeptide-12.

PALMITOYL OLIGOPEPTIDE is an active ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

PALMITOYL OLIGOPEPTIDE is a peptide—a short chain of amino acids—with a palmitic acid (a fatty acid) attached via a process called palmitoylation. This modification influences how proteins behave inside cells. For skincare specifically, research has examined a similar palmitoylated peptide called palmitoyl-RGD (PAL-RGD). According to a 2022 study in *Molecular Medicine Reports*, #1: topical treatment with PAL-RGD improved facial wrinkles, skin elasticity, and dermal density in human volunteers. In laboratory tests using human skin cells (keratinocytes), #2: PAL-RGD increased production of three key structural proteins—laminin-332, collagen IV, and collagen XVII—in a dose-dependent manner (meaning higher concentrations produced stronger effects). These proteins are crucial components of the dermal-epidermal junction (DEJ), the boundary layer between the outer skin and deeper layers.

#3: As skin ages, this junction naturally thins and loses these proteins, which is thought to contribute to wrinkles and loss of firmness. More broadly, palmitoylation itself plays important roles in cell biology. According to a 2012 review in *Antioxidation & Redox Signaling*, palmitoylation affects protein trafficking, localization within cells, and cellular signaling. However, the sources provided do not contain direct evidence that PALMITOYL OLIGOPEPTIDE specifically delivers these benefits in human skin beyond the PAL-RGD study mentioned. The research on PALMITOYL OLIGOPEPTIDE as an ingredient is limited; most supportive data comes from a related—but not identical—compound tested in both cells and a small human study.

💧 Skin Type Compatibility

⚠️ Don’t Combine With

🧴 Products Containing PALMITOYL OLIGOPEPTIDE

• Fragonard Crème antirides pour le visage Vrai
• RoC RoC Multi Correxion 5 in 1 Anti-Aging Eye Cream
• StriVectin StriVectin Anti-Wrinkle Intensive Eye Cream
• henkel, diadermine, Diadermine Expert Rides 3D Activateur Hyaluronique Crème Anti-rides Nuit
• Henkel, Diadermine Expert rides 3D – Soin anti-rides haute performance nuit
• Vichy Liftactiv Serum 10 Yeux et Cils
• Guerlain Abeille Royale – Masque Gel Miel Réparateur
• Новая Заря Крем для рук питательный Интенсивное Восстановление
• Henkel, Diadermine Dr. Caspari Combleur Rides
• Rimmel Hydra renew
• Henkel, Diadermine Jeunesse infusée concentré anti-rides
• L’Oréal, L’Oréal Men Expert Hydra Energetic Bille glacée Yeux anti-poches + anti-cernes
• RoC RoC Derm Correxion Dual Eye Cream with Advanced Retinol

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Lin J et al. (2026). ATAD3A Limits Aortic Dissection via Mito-Lysosome Contacts and Lipoylation. Circ Res.
• Jortzik E et al. (2012). Thiol-based posttranslational modifications in parasites. Antioxid Redox Signal.
• Lim JH et al. (2022). Palmitoyl‑RGD promotes the expression of dermal‑epidermal junction components in HaCaT cells. Mol Med Rep.
• Heras AF et al. (2020). Increasing Sphingolipid Synthesis Alleviates Airway Hyperreactivity. Am J Respir Cell Mol Biol.
• Teuber JP et al. (2025). Rac1 palmitoylation is required for cardiac stress adaptation and regulation of protein kinase A signaling. JCI Insight.