PIROCTONE OLAMINE

EU max concentration: Maximum secondary amine content: 0.5%

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

Piroctone olamine is a salt form of the antifungal compound piroctone, specifically designed for topical use on skin and scalp (Int J Cosmet Sci, 2023). Dandruff and its more severe form, seborrheic dermatitis, are linked to a combination of factors including disruption of the scalp’s protective barrier and overgrowth of microorganisms, particularly the fungus Malassezia (Int J Cosmet Sci, 2024). #1: The ingredient works as an antifungal agent to manage dandruff (Int J Cosmet Sci, 2023). #2: Research using DNA sequencing of scalp microbiomes shows that after 3 weeks of treatment with a 0.5% piroctone olamine shampoo, the ingredient reduces levels of problematic organisms like Malassezia restricta and Staphylococcus capitis while increasing beneficial Cutibacterium acnes, essentially restoring a healthier microbial balance (Int J Cosmet Sci, 2024).

The same study found that these microbiome changes correlated with reduced oxidative stress markers on the scalp (Int J Cosmet Sci, 2024). #3: In a clinical study of 20 patients with moderate to severe scalp seborrheic dermatitis treated with a combination product containing piroctone olamine, dandruff scores dropped significantly from 2.45 to 1.10 by week 4, itching decreased from 2.35 to 1.10, redness went from 1.55 to 1.10, and greasiness fell from 2.60 to 1.40 (J Cosmet Dermatol, 2025). After 16 weeks, 80% of patients showed overall clinical improvement, with severe cases improving to mild status (J Cosmet Dermatol, 2025).

The physicochemical properties of piroctone olamine—how it dissolves and behaves in different liquids—affect how well it penetrates and deposits on skin (Int J Cosmet Sci, 2023). It dissolves best in methanol and propylene glycol but shows poor solubility in some other solvents, and it remains stable in ethanol and propylene glycol systems but degrades in water-based solutions over several days (Int J Cosmet Sci, 2023). #4: How effectively piroctone olamine reaches your scalp depends heavily on the delivery system: in laboratory testing with human skin, no permeation occurred when the ingredient was dissolved in single solvents alone, but permeation increased significantly when combined in two- or three-component solvent systems, with the best results from specific propylene glycol and Transcutol combinations (Int J Cosmet Sci, 2024).

#5: Formulation innovations that optimize how piroctone olamine binds to or releases from shampoo ingredients have been shown to increase its scalp deposition and improve clinical anti-dandruff efficacy as measured by visible flake reduction and underlying biomarkers (Int J Cosmet Sci, 2023). The sources note these are emerging findings and that products vary in their formulation strategies to maximize delivery.

💧 Skin Type Compatibility

⚠️ Don’t Combine With

🧴 Products Containing PIROCTONE OLAMINE

• Nivea, Nivea Men NIVEA Men Hyaluron Anti-age Gezichtscrème
• Nivea, Nivea Men Power Shampoo Anti-pelliculaire
• BRYNILD GRUPPEN AS Nivea Sensitive Day Care 50ml
• Gillette UK LTD Old Spice WOLFTHORN
• GEHWOL med Express Pflege-Schaum
• H&S Champú
• Procter & gamble as Head&Shoulders Shampoo Classic Clean 400ml
• Glynt Derma Shampoo
• Seinz., dm shampoo anti-schuppen (minze 3-fach-komplex)
• Balea,Balea med,dm,dm – drogerie markt,drogerie markt 5% UREA – DUSCHE+SHAMPOO
• Lacura Classic Anti-dandruff Shampoo
• V.Sun Catch the sun
• Heads and shoulders Smooth and silky heads and shoulders anti dandruff shampoo
• Calypso facial protection
• LILLEBORG AS Dr Greve Aloe Vera Body Lotion 200ml
• Head & Shoulders Apple Fresh
• Procter & Gamble Head and Shoulders
• PROCTER & GAMBLE NORGE AS Head & Shoulder Shampoo Supreme Repair 225ml
• head & shoulders OXYGENATED CHARCOAL DETOX
• head & shoulders Intense hydration

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Tang CF et al. (2023). Characterization of piroctone olamine for topical delivery to the skin. Int J Cosmet Sci.
• Tang CF et al. (2024). Investigation of piroctone olamine delivery to the skin from single, binary and ternary solvent systems. Int J Cosmet Sci.
• Ge L et al. (2025). A Cohort Clinical Study on the Efficacy of Topical Salicylic Acid/Piroctone Olamine Dandruff Pre-Gel and Cleanser in Improving Symptoms of Moderate to Severe Seborrheic Dermatitis of the Scalp. J Cosmet Dermatol.
• Hu P et al. (2024). Scalp microbiome composition changes and pathway evaluations due to effective treatment with Piroctone Olamine shampoo. Int J Cosmet Sci.
• Johnson ES et al. (2023). Enhanced piroctone olamine retention from shampoo for superior anti-dandruff efficacy. Int J Cosmet Sci.