POLYGLUTAMIC ACID

Description: POLYGLUTAMIC ACID — hydration, film-forming (holds moisture comparably to hyaluronic acid).

All Functions: hydration, film-forming (holds moisture comparably to hyaluronic acid)

Quick Facts:

• Category: humectant

Proven Benefits At A Glance:

• Polyglutamic acid is a water-soluble, biocompatible polymer made from natural sources
• It’s environmentally friendly and has been used in medicine, food, and cosmetics research
• The ingredient shows promise in stabilizing and slowly releasing other active compounds
• Research suggests it can improve the texture and stability of gel-based formulations
• It appears to have antioxidant properties in laboratory studies

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 POLYGLUTAMIC ACID

POLYGLUTAMIC ACID

CAS Number: 25513-46-6

Also Known As: —

Category: humectant

Korean Name: 폴리글루타믹애씨드

Polymer of glutamic acid

POLYGLUTAMIC ACID is a humectant ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

Polyglutamic acid (specifically γ-polyglutamic acid) is a naturally occurring polymer—essentially a chain of amino acids linked together—that dissolves easily in water and works well with living tissues without causing harm (Curr Drug Deliv, 2024). Here’s what the research shows about how it might work in skincare:

#1: Ingredient stabilization and delivery. Polyglutamic acid can be formed into tiny nanoparticles that encapsulate and slowly release other active ingredients. This slow-release effect reduces irritation from those actives while potentially making them more effective. The particles are simple to produce without toxic byproducts (Curr Drug Deliv, 2024). In wound-healing studies, when polyglutamic acid nanoparticles were combined with other compounds, they showed 17 times better retention at the site of injury compared to the active ingredient alone (Int J Pharm, 2023).

#2: Texture and formulation benefits. When added to gel formulations, polyglutamic acid increases viscosity (thickness), improves water-holding capacity, and creates a more stable, uniform structure. At low concentrations (around 0.1%), it enhanced stability and even distribution of particles within the gel (Front Nutr, 2024). This means products containing it may feel more luxurious and stay stable longer on the shelf. #3: Antioxidant activity. Laboratory testing found that polyglutamic acid derived from fermented sources showed antioxidant properties (Front Microbiol, 2025), though the sources don’t specify how significant this is in skincare applications or at what concentrations it becomes meaningful. Important limitations: Most research on polyglutamic acid involves it as a carrier for other drugs or actives rather than as a standalone skincare ingredient.

The wound-healing studies used it in nanoparticle form combined with other compounds like curcumin or doxycycline (Int J Pharm, 2023; Int J Biol Macromol, 2024), so we don’t know from these sources alone how effective it is by itself. None of the abstracts specifically test polyglutamic acid on healthy skin.

💧 Skin Type Compatibility

⚠️ Don’t Combine With

🧴 Products Containing POLYGLUTAMIC ACID

• Karseell Maca Essential Oil
• OleHenriksen,Ole Henriksen Banana Bright+ Instant Glow Moisturizer
• Typology Acide polyglutamique 3% + Extrait d’algue rouge
• Mad Hippie Daily protective serum.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Liu Z et al. (2024). Preparation, Characterization and Drug Delivery Research of γ-Polyglutamic Acid Nanoparticles: A Review. Curr Drug Deliv.
• He S et al. (2023). A polyglutamic acid/tannic acid-based nano drug delivery system: Antibacterial, immunoregulation and sustained therapeutic strategies for oral ulcers. Int J Pharm.
• Xie H et al. (2024). Rheology, physicochemical properties, and microstructure of fish gelatin emulsion gel modified by γ-polyglutamic acid. Front Nutr.
• Manika V et al. (2025). Microbial production and functional assessment of γ-polyglutamic acid isolated from Bacillus sp. M-E6. Front Microbiol.
• Cheng C et al. (2024). Examining the wound healing potential of curcumin-infused electrospun nanofibers from polyglutamic acid and gum arabic. Int J Biol Macromol.