VITIS VINIFERA SEED OIL

📋 Quick facts

Description: VITIS VINIFERA SEED OIL — moisturizing, antioxidant (Grapeseed Oil).

All Functions: moisturizing, antioxidant (Grapeseed Oil)

Quick Facts:

• Category: emollient
• Comedogenic Rating: 1/5

Proven Benefits At A Glance:

• Vitis vinifera seed oil contains compounds called phenolics and phytosterols that have antioxidant properties
• Research on a specific extract (unsaponifiable fraction) from black grape seed oil showed anti-cancer activity in laboratory and animal studies
• The extract demonstrated strong antioxidant capacity and safety in human cell tests
• Animal studies showed the extract improved liver function markers and reduced inflammation

⚗️ Chemical Overview

Water appears as a clear, nontoxic liquid composed of hydrogen and oxygen, essential for life and the most widely used solvent. Include water in a mixture to learn how it could react with other chemicals in the mixture. Water is an oxygen hydride consisting of an oxygen atom that is covalently bonded to two hydrogen atoms. It has a role as an amphiprotic solvent, a mouse metabolite, a Saccharomyces cerevisiae metabolite, a member of greenhouse gas, an Escherichia coli metabolite and a human metabolite. It is an oxygen hydride, a mononuclear parent hydride and an inorganic hydroxy compound. It is a conjugate base of an oxonium. It is a conjugate acid of a hydroxide. Water (chemical formula: H2O) is a transparent fluid which forms the world’s streams, lakes, oceans and rain, and is the major constituent of the fluids of organisms. As a chemical compound, a water molecule contains one oxygen and two hydrogen atoms that are connected by covalent bonds. Water is a liquid at standard ambient temperature and pressure, but it often co-exists on Earth with its solid state, ice; and gaseous state, steam (water vapor).

Source(s): ChEBI, CAMEO Chemicals, DrugBank, via PubChem

📊 Comedogenicity

1/5

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

Derived from this ingredient’s irritancy potential and comedogenicity rating against the needs of each skin type — e.g. oily and acne-prone skin are marked down for pore-clogging ingredients, sensitive skin for irritants. A starting heuristic, not a dermatological verdict.

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Vitis vinifera seed oil—oil extracted from grape seeds—contains natural compounds that researchers have begun studying for potential health applications. Most skincare consumers encounter this ingredient in serums and moisturizers, though the research we have focuses on a specialized extract rather than the oil itself as typically used in consumer products. The available research examines something called the “unsaponifiable fraction” (UnSap) from black Vitis vinifera seed oil, which is the portion of the oil that doesn’t saponify—a technical term meaning it doesn’t convert to soap when treated with alkaline chemicals. This fraction is enriched in phenolic compounds and phytosterols, plant-derived molecules with antioxidant properties (Sci Rep, 2026).

#1: Antioxidant capacity—Laboratory testing found this extract had strong antioxidant capacity and demonstrated what researchers call a “higher selectivity index” against liver cancer cells compared to the chemotherapy drug 5-fluorouracil, meaning it affected cancer cells more effectively while showing excellent safety in human immune cells (Sci Rep, 2026). #2: Gene expression changes—In animal studies, the extract modulated expression of genes involved in multiple processes: apoptosis (programmed cell death, showing >20-fold changes), cell cycle regulation (>fourfold), inflammation (>fivefold), and angiogenesis or blood vessel formation (threefold) (Sci Rep, 2026). #3: Liver health markers—In liver cancer-bearing mice, the extract improved serum liver function markers (0.4-1.3-fold improvement) and restored redox balance, a measure of antioxidant status (>threefold improvement) (Sci Rep, 2026).

Importantly, this research was conducted on a specialized extract in laboratory and animal models—not on the cosmetic ingredient as consumers would use it. The findings are preliminary and do not yet translate to proven benefits in human skin applications.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Abu-Serie MM et al. (2026). Unsaponifiable fraction of black Vitis vinifera seed oil attenuates liver cancer progression by targeting apoptosis and key tumor-associated genes: In vitro, in vivo, and in silico studies. Sci Rep.

🧴 Products Containing VITIS VINIFERA SEED OIL

• Nivea Nivea Intensive Moisture Body Milk 5-in-1 Complete Care (or Nivea Nourishing Body Milk)
• Nivea Care Shower Rose & Almond Oil
• BRYNILD GRUPPEN AS Nivea Sensitive Day Care 50ml
• Nivea nivea bronze efect
• gillette Venus Extra Smooth
• Fair squared products Coffee body lotion
• Alterra Hydro Tagescreme Bio-Traube & Bio-Weisser Tee
• Beiersdorf Nivea Ansiktsmaske Urban Skin Radience 1stk
• Nacomï White Black Face Mask
• Arad Body Soufflé
• Swiss Toniq Geneva Moisturising Rose & Lavender Cream Soap – Box
• Swiss Toniq Geneva Double Stem Cell Repair 11-in-1 Serum With Essential Oil
• Swiss Toniq Geneva Allergic Skin Cleansing Bar – Bag
• Swiss Toniq Geneva New Skin Moisturising Facial Polish Exfoliant
• Swiss Toniq Geneva Cellular Sun Defence Face & Body Sunscreen 30SPF
• Swiss Toniq Geneva Time Response 11-in-1 Serum With Essential Oil
• Swiss Toniq Geneva Advanced Repair 11-in-1 Serum Without Essential Oil
• Fragonard Crème antirides pour le visage Vrai
• Swiss Toniq Geneva Charcoal & Dead Sea Salt Detox Soap – Bag
• du monde à la Provence Flora : crème jour à l’argan bio parfum rose
• Caudalie Crème gourmande mains et ongles – Thé des vignes
• Manufaktura Original Home Spa Beer Cosmetics
• Yves Rocher Pure calmille depuis 1964 since
• CREAM.LY CREAM MY SKIN (Normal/Mixed/Oily)
• CREAM.LY NOURISH MY SKIN (Normal/Mixed/Oily)
• L’Oréal, L’Oreal Consumer products, Garnier, 100% Ultra Color 100% ultra color Noir bleu 210
• U, U Tout petits Huile de soin douce raffinée
• Biocos, Kariline Lait corps nutritif au karité bio
• Puressentiel Huile Sèche Minceur
• du monde à la provence Alissa : crème jour au lait d’ânesse bio parfum Mystère du Nil
• Du monde à la Provence, dmp Gaïa : crème jour à l’huile de pépins de raisin parfum muscat
• Du monde à la provence Ayana crème de jour parfum fleur de cerisier
• Du monde à la provence Ayana crème nuit parfum fleur de cerisier
• Caudalie Crème réparatrice mains & ongles – thé des vignes
• Caudalie Crème gourmande mains et ongles Rose de Vigne
• Carrefour Soin Nourrissant Pieds Secs
• Swiss Toniq Geneva Moisturizing Aloe Vera & Jasmine Cream Soap – Bag
• L’OREAL NORGE AS Nutrisse 7.3 Gyldenblond
• L’OREAL NORGE AS Nutrisse 9 Meget Lysblond
• L’OREAL NORGE AS Nutrisse 4.15 Marron Glace