VITIS VINIFERA SEED OIL

Description: VITIS VINIFERA SEED OIL — moisturizing, antioxidant (Grapeseed Oil).

All Functions: moisturizing, antioxidant (Grapeseed Oil)

Quick Facts:

• Category: emollient
• Comedogenic Rating: 1/5

Proven Benefits At A Glance:

• Vitis vinifera seed oil contains compounds called phenolics and phytosterols that have antioxidant properties
• Research on a specific extract (unsaponifiable fraction) from black grape seed oil showed anti-cancer activity in laboratory and animal studies
• The extract demonstrated strong antioxidant capacity and safety in human cell tests
• Animal studies showed the extract improved liver function markers and reduced inflammation

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 VITIS VINIFERA SEED OIL

VITIS VINIFERA SEED OIL

CAS Number: 85594-37-2 / 84929-27-1 / 8024-22-4

Also Known As: —

Category: emollient

EC Number: 287-896-9 / 284-511-6 / –

Vitis Vinifera Seed Oil is the fixed oil, consisting primarily of the glycerides of the fatty acids, obtained by pressing the seeds of the Grape, Vitis Vinifera L., Vitaceae

VITIS VINIFERA SEED OIL is an emollient ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

1/5

📚 Research & Evidence

🔬 The Science

Vitis vinifera seed oil—oil extracted from grape seeds—contains natural compounds that researchers have begun studying for potential health applications. Most skincare consumers encounter this ingredient in serums and moisturizers, though the research we have focuses on a specialized extract rather than the oil itself as typically used in consumer products. The available research examines something called the “unsaponifiable fraction” (UnSap) from black Vitis vinifera seed oil, which is the portion of the oil that doesn’t saponify—a technical term meaning it doesn’t convert to soap when treated with alkaline chemicals. This fraction is enriched in phenolic compounds and phytosterols, plant-derived molecules with antioxidant properties (Sci Rep, 2026).

#1: Antioxidant capacity—Laboratory testing found this extract had strong antioxidant capacity and demonstrated what researchers call a “higher selectivity index” against liver cancer cells compared to the chemotherapy drug 5-fluorouracil, meaning it affected cancer cells more effectively while showing excellent safety in human immune cells (Sci Rep, 2026). #2: Gene expression changes—In animal studies, the extract modulated expression of genes involved in multiple processes: apoptosis (programmed cell death, showing >20-fold changes), cell cycle regulation (>fourfold), inflammation (>fivefold), and angiogenesis or blood vessel formation (threefold) (Sci Rep, 2026). #3: Liver health markers—In liver cancer-bearing mice, the extract improved serum liver function markers (0.4-1.3-fold improvement) and restored redox balance, a measure of antioxidant status (>threefold improvement) (Sci Rep, 2026).

Importantly, this research was conducted on a specialized extract in laboratory and animal models—not on the cosmetic ingredient as consumers would use it. The findings are preliminary and do not yet translate to proven benefits in human skin applications.

💧 Skin Type Compatibility

Derived from this ingredient’s irritancy potential and comedogenicity rating against the needs of each skin type — e.g. oily and acne-prone skin are marked down for pore-clogging ingredients, sensitive skin for irritants. A starting heuristic, not a dermatological verdict.

⚠️ Don’t Combine With

🧴 Products Containing VITIS VINIFERA SEED OIL

• Nivea Nivea Intensive Moisture Body Milk 5-in-1 Complete Care (or Nivea Nourishing Body Milk)
• BRYNILD GRUPPEN AS Nivea Sensitive Day Care 50ml
• Nivea Care Shower Rose & Almond Oil
• Beiersdorf Nivea Ansiktsmaske Urban Skin Radience 1stk
• Nivea nivea bronze efect
• gillette Venus Extra Smooth
• Fair squared products Coffee body lotion
• Alterra Hydro Tagescreme Bio-Traube & Bio-Weisser Tee
• Fragonard Crème antirides pour le visage Vrai
• Nacomï White Black Face Mask
• Arad Body Soufflé
• Swiss Toniq Geneva Moisturising Rose & Lavender Cream Soap – Box
• Swiss Toniq Geneva Double Stem Cell Repair 11-in-1 Serum With Essential Oil
• Swiss Toniq Geneva Allergic Skin Cleansing Bar – Bag
• Swiss Toniq Geneva New Skin Moisturising Facial Polish Exfoliant
• Swiss Toniq Geneva Cellular Sun Defence Face & Body Sunscreen 30SPF
• Swiss Toniq Geneva Time Response 11-in-1 Serum With Essential Oil
• Swiss Toniq Geneva Advanced Repair 11-in-1 Serum Without Essential Oil
• Swiss Toniq Geneva Moisturizing Aloe Vera & Jasmine Cream Soap – Bag
• Swiss Toniq Geneva Charcoal & Dead Sea Salt Detox Soap – Bag

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Abu-Serie MM et al. (2026). Unsaponifiable fraction of black Vitis vinifera seed oil attenuates liver cancer progression by targeting apoptosis and key tumor-associated genes: In vitro, in vivo, and in silico studies. Sci Rep.