GLYCYRRHIZA GLABRA ROOT EXTRACT

📋 Quick facts

Description: GLYCYRRHIZA GLABRA ROOT EXTRACT — soothing, brightening, anti-inflammatory (Licorice Root).

All Functions: soothing, brightening, anti-inflammatory (Licorice Root)

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• Glycyrrhiza glabra (licorice) root extract has antibacterial activity against Streptococcus mutans, a bacteria linked to dental caries
• Ethanolic (alcohol-based) licorice root extract showed stronger antibacterial effects than aqueous (water-based) forms in lab testing
• The antibacterial potency of ethanolic licorice root extract was comparable to chlorhexidine, a common antimicrobial agent used in mouthwash
• Licorice root is considered economically accessible and culturally accepted as a plant-based alternative

⚗️ Chemical Overview

Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2′ and 4′ and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan. (R)-Glabridin has been reported in Glycyrrhiza glabra and Glycyrrhiza inflata with data available. glabridin has been reported in Glycyrrhiza uralensis, Ornithopus sativus, and other organisms with data available.

Source(s): ChEBI, LOTUS – the natural products occurrence database, via PubChem

📊 Comedogenicity

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

Derived from this ingredient’s irritancy potential and comedogenicity rating against the needs of each skin type — e.g. oily and acne-prone skin are marked down for pore-clogging ingredients, sensitive skin for irritants. A starting heuristic, not a dermatological verdict.

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Glycyrrhiza glabra root extract (commonly called licorice root) has demonstrated antibacterial properties in laboratory research. #1: When tested against Streptococcus mutans—a oral bacterium associated with tooth decay—the ethanolic (alcohol-extracted) form of licorice root produced a zone of inhibition of 22.4 mm, nearly matching chlorhexidine mouthwash at 23 mm, according to the Journal of Contemporary Dental Practice (2019). The aqueous (water-extracted) version was less potent at 15.8 mm. #2: The minimum inhibitory concentration—the lowest concentration needed to stop bacterial growth—was 12.5 mg/mL for the ethanolic extract and 20 mg/mL for the aqueous extract, per the same source. These findings come from controlled laboratory assays (agar ditch and broth dilution methods) rather than human clinical trials.

The research notes that licorice root is readily available and economically feasible compared to conventional antimicrobial agents, though the sources provided do not include data on anti-inflammatory effects, long-term safety in skincare products, or efficacy in actual oral or skin applications outside the lab setting.

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Malvania EA et al. (2019). In Vitro Analysis of Licorice (Glycyrrhiza glabra) Root Extract Activity on Streptococcus mutans in Comparison to Chlorhexidine and Fluoride Mouthwash. J Contemp Dent Pract.

🧴 Products Containing GLYCYRRHIZA GLABRA ROOT EXTRACT

• lipsan
• nivea hand cream 3 in 1 repaircare
• Tandpasta
• Eveline Cosmetics Cooling compress hydrogel eye pads
• SB Mask with glitter
• maharishi ayurveda maharishi toothpaste
• soap
• Balea Niacinamide Tagescreme
• Nivea NIVEA CREME DARK SPOT REDUCTION
• Cattier Cattier Bain de bouche fraîcheur
• Sanaka bio Crème de jour au cbd
• Weleda Fluide matifiant
• Puressentiel Complément anti-chute
• Nocibe Masque confort apaisant fleur de coton & reglisse
• Nivea EXTRA WHITE PORE MINIMISER MUD FOAM
• Nivea Protect & Care Pocket
• happybrush Repair & Care
• Alterra Sport Deo-Spray Bio-Lemongras, Koffein
• Natura Siberica La force du loup
• Boob tape remover
• urtekram baobab aloe vera men deo
• Ballot-flurin Bain de bouche aux microbulles de propolis blanche
• Erborian Masque visage sublimant au magnolia
• Null masque
• Glow Lab Glow Lab Hydra gel moisturiser
• sand
• Lush Coalface
• yves rocher White botanical