PALMITOYL TETRAPEPTIDE-7

Description: PALMITOYL TETRAPEPTIDE-7 — peptide, anti-inflammatory, supports skin firmness.

All Functions: peptide, anti-inflammatory, supports skin firmness

Quick Facts:

• Category: active

Proven Benefits At A Glance:

• A peptide ingredient used in anti-aging eye creams and sensitive skin products
• In a 12-week clinical trial, an eye cream containing this ingredient (plus others) improved skin hydration by 28%, elasticity by 19%, and collagen by 55%
• Laboratory studies show it can stimulate collagen and elastin production in skin cells
• Found in about 17% of facial cosmetics marketed for sensitive skin
• Generally considered safe based on available clinical data

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 PALMITOYL TETRAPEPTIDE-7

PALMITOYL TETRAPEPTIDE-7

CAS Number: 221227-05-0

Also Known As: —

Category: active

EC Number: –

Korean Name: 팔미토일테트라펩타이드-7

Palmitoyl Tetrapeptide-7 is the reaction product of palmitic acid and Tetrapeptide-7.

PALMITOYL TETRAPEPTIDE-7 is an active ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

Palmitoyl tetrapeptide-7 is a peptide—a short chain of amino acids—designed to interact with skin cells. Peptides are valued in skincare because they can work at low doses and may penetrate the outer layer of skin called the stratum corneum (Pharmaceuticals (Basel), 2021). In laboratory tests using human skin fibroblasts (the cells that produce structural proteins), the ingredient demonstrated #1: the ability to stimulate cell growth and #2: increased production of collagen and elastin, which are key proteins that give skin its firmness and structure (Skin Res Technol, 2024). Clinically, when tested as part of an anti-aging eye cream formula alongside other active ingredients (yeast/rice fermentation filtrate, N-acetylneuraminic acid, and palmitoyl tripeptide-1), the 12-week results showed measurable improvements in the delicate eye area: skin hydration increased 28.12%, elasticity improved 18.81%, and collagen density rose 54.99% (Skin Res Technol, 2024).

Participants and dermatologists noted visible improvements in fine lines, wrinkles, roughness, and skin moisture by week 8. A separate study using advanced imaging techniques (MALDI-MSI, confocal microscopy, and ultrasound) examined a blend containing palmitoyl tetrapeptide-7 alongside palmitoyl oligopeptide. The peptide combination showed #3: improvements in the extracellular matrix structure of the dermis (the layer beneath the epidermis) and #4: reduced thickness of the subepidermal low-echogenic band, suggesting better skin density (J Cosmet Dermatol, 2015). Importantly, the research on peptides in sensitive skin cosmetics notes that while palmitoyl tetrapeptide-7 appears in products marketed for sensitivity, most evidence comes from supplier data and patents rather than rigorous placebo-controlled clinical studies (Pharmaceuticals (Basel), 2021).

The ingredient has been explored in medical applications beyond cosmetics—for instance, in wound-healing hydrogels—but consumer skincare claims should be understood within the limited cosmetic evidence available.

💧 Skin Type Compatibility

Derived from this ingredient’s irritancy potential and comedogenicity rating against the needs of each skin type — e.g. oily and acne-prone skin are marked down for pore-clogging ingredients, sensitive skin for irritants. A starting heuristic, not a dermatological verdict.

⚠️ Don’t Combine With

🧴 Products Containing PALMITOYL TETRAPEPTIDE-7

• Fragonard Crème antirides pour le visage Vrai
• Clinique Fresh Pressed 7-Day System with Pure Vitamin C
• Les Cosmetiques Crema antiedad de día para piel mixta y grasa booster plan
• Les Cosmetiques Crema antiedad de día para piel normal y seca booster plan
• Les Cosmetiques Crema para contorno de ojos booster plan
• Les Cosmetiques Gel contorno de ojos aplicador frio booster plan
• Les Cosmetiques Booster iluminador les cosmetiques nº1 booster plan
• Les Cosmetiques Booster antifatiga les cosmetiques nº2 booster plan
• Les Cosmetiques Booster radiante les cosmetiques nº3 booster plan
• Les Cosmetiques Booster tonificante les cosmetiques nº4 booster plan
• Les Cosmetiques Booster efecto barrera les cosmetiques nº6 booster plan
• Les Cosmetiques Booster detox les cosmetiques nº7 booster plan
• Les Cosmetiques Booster regenerador les cosmetiques nº9 booster plan
• Les Cosmetiques Mascarilla facial de arcilla booster plan
• Deliplus Sensitive cream
• RoC RoC Multi Correxion 5 in 1 Anti-Aging Eye Cream
• StriVectin StriVectin Anti-Wrinkle Intensive Eye Cream
• e.l.f. Cosmetics Holy Hydration! Daily Cleanser
• Organic & Botanic Mandarin Orange Enhacing Day Moisturiser
• Mineral Fusion Revitalizing Eye Treatment

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Yang F et al. (2024). Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream. Skin Res Technol.
• Resende DISP et al. (2021). Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel).
• Xing C et al. (2025). Injectable polypeptide/chitosan hydrogel with loaded stem cells and rapid gelation promoting angiogenesis for diabetic wound healing. Int J Biol Macromol.
• Mondon P et al. (2015). Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications. J Cosmet Dermatol.