SODIUM PHYTATE

Description: SODIUM PHYTATE — chelating agent, antioxidant support, stabilizes formulations.

All Functions: chelating agent, antioxidant support, stabilizes formulations

Quick Facts:

• Category: other

Proven Benefits At A Glance:

• Sodium phytate is a calcium-binding compound (chelating agent) that’s described as environmentally friendly and non-harmful
• Research shows it may help remove surface stains on teeth when included in toothpaste
• One clinical trial found it improved smell loss in COVID-19 patients by reducing calcium buildup in nasal secretions
• Tooth whitening effects appear strongest in the first 3 weeks of use; benefits plateau after 4 weeks
• Studies report it was generally well-tolerated with no significant adverse events mentioned

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🧪 SODIUM PHYTATE

SODIUM PHYTATE

CAS Number: 14306-25-3 / 34367-89-0

Also Known As: —

Category: other

EC Number: 238-242-6

Korean Name: 소듐파이테이트

Myo-Inositol, hexakis(dihydrogen phosphate), sodium salt

SODIUM PHYTATE is an other ingredient used in skincare formulations.

🌍 Regulatory Status

📊 Comedogenicity

📚 Research & Evidence

🔬 The Science

Sodium phytate is an organic compound related to polyphosphates—materials that can bind to calcium and remove surface stains. Here’s what research actually shows:

#1: Tooth stain removal — Multiple studies tested sodium phytate in toothpaste formulations at concentrations between 0.5% and 0.875%. A 2018 study (J Esthet Restor Dent) comparing an experimental toothpaste with 0.85% sodium phytate to a reference toothpaste found statistically significantly lower stain scores at both 6 and 12 weeks, with particularly strong results in hard-to-reach areas like between teeth and along the gum line. A 2021 study (BMC Oral Health) using a toothpaste containing 0.5% sodium phytate alongside other ingredients showed 26–42% reductions in stain measurements over 8 weeks.

However, a 2025 trial (Clin Oral Investig) with 0.875% sodium phytate found whitening effects peaked around 3 weeks and showed minimal additional stain removal benefit after 4 weeks, though tooth brightness measurements (L-value) continued improving slightly. Importantly, participant satisfaction with tooth color showed no statistically significant differences between sodium phytate toothpaste and control toothpaste in that 2025 study. #2: Smell restoration after COVID-19 — One 2024 clinical trial (Am J Rhinol Allergy) tested nasal spray containing 1% sodium phytate in 26 patients with lasting smell loss from COVID-19. The reasoning was that excess calcium in nasal mucus can damage smell receptors; sodium phytate binds calcium and theoretically prevents this damage.

After one month, patients using sodium phytate showed improvement from complete loss of smell to partial loss, while the comparison group using saline spray showed no improvement. Calcium levels in nasal secretions also decreased after sodium phytate treatment. This is the only skincare-adjacent research on sodium phytate, and it focuses on nasal application rather than topical skincare. Limitations: Tooth-stain research involved small to moderate sample sizes (80–224 participants). The smell-loss study included only 52 patients. No studies directly assessed sodium phytate in other skincare applications like anti-aging or general skin health. The tooth-whitening research measured objective stain reduction, but one trial found no significant difference in how satisfied users were with results.

💧 Skin Type Compatibility

⚠️ Don’t Combine With

🧴 Products Containing SODIUM PHYTATE

• DM alverde Active Nature Shampoo
• Lavera Anti-Schuppen-Schampoo
• Lavera Shampooing anti-pelliculaire
• DM Alverde Naturkosmetik Shampoo Feuchtigkeit Aloe Vera & Hyaluron
• eco elio Alles Routine nachhaltige Sonnencreme
• Facetheory Glow-C Cream Cleanser
• Apivita Shower gel with essential oils- refreshing fig
• KORRES Travel Size Greek Yoghurt Foaming Cream Cleanser
• Crema verbal corporal de Sandalo – Just
• vivi verde shampoo antiforfora
• Coop, Viviverde Ricarica sapone liquido delicato
• So’bio etic Shampooing doux Lait d’ânesse et d’amande
• Léa Nature, So’ Bio étic BB cream texture légère perfecteur de teint – 01 beige nude
• Léa Nature So’bio étic Précieux Argan- Sérum éclat anti-age
• Caudalie Crème sorbet hydratant Vinosource
• Naturaverde Aloe e Menta Detergente intimo
• Le petit marseillais Crème hydratante Visage & corps Olive & Amande douce
• Laboratoires Vendome, Vendome Douche & Bain Émollient Surgras Peaux sèches
• Le Petit Marseillais Lait de Vanille Douche crème extra doux
• Cosmia Bio Recharge creme visage eclat a la vitamine c

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Altemani AH et al. (2024). The Efficacy of Sodium Phytate as a Natural Chelating Agent in Reducing Elevated Calcium Levels in Nasal Mucus Among Individuals Experiencing Olfactory Dysfunction Following COVID-19: A Prospective Randomized Double-Controlled Clinical Trial. Am J Rhinol Allergy.
• Liu H et al. (2021). Reduction of extrinsic tooth stain by a toothpaste containing 10% high cleaning silica, 0.5% sodium phytate and 0.5% sodium pyrophosphate: an 8-week randomised clinical trial. BMC Oral Health.
• Cui T et al. (2025). Whitening efficacy and removal of extrinsic tooth stain of sodium phytate-containing whitening toothpaste: a randomized controlled trial. Clin Oral Investig.
• Gaffar A et al. (1982). Effects of sodium phytate and benzethonium chloride rinses on plaque formation in humans. Caries Res.
• Milleman KR et al. (2018). A randomized clinical trial to evaluate the stain removal efficacy of a sodium phytate dentifrice formulation. J Esthet Restor Dent.