Sodium Lauryl Sulfate

📋 Quick facts

Description: Sodium Lauryl Sulfate — cleansing, foaming.

All Functions: cleansing, foaming

Quick Facts:

• Category: surfactant
• Also Known As: SLS
• Comedogenic Rating: 0/5

Proven Benefits At A Glance:

• SLS is commonly used in skincare and oral care products as a cleaning agent
• About 20-22% of people react to SLS in patch tests, though most reactions are mild
• SLS can cause skin irritation, redness, and swelling in some individuals
• For people with recurrent mouth ulcers, SLS-free toothpaste may help reduce ulcer frequency and pain
• The reasons why some people react to SLS are not fully understood

⚗️ Chemical Overview

Dodecyl hydrogen sulfate is an alkyl sulfate. It is a conjugate acid of a dodecyl sulfate. MOTZDAYCYVMXPC-UHFFFAOYSA-N has been reported in Trypanosoma brucei with data available. RN given refers to parent cpd; see also SODIUM DODECYL SULFATE

Source(s): LOTUS – the natural products occurrence database, ChEBI, Medical Subject Headings (MeSH), via PubChem

📊 Comedogenicity

0/5

🛡️ Safety rating

Safety tier is a starting heuristic from regulatory status and comedogenic rating, not a dermatological verdict — see our Terms for the full disclaimer. Research confidence reflects how many real cited studies back this ingredient, not the strength of their findings.

🌍 Regulatory Status

💧 Skin Type Compatibility

Derived from this ingredient’s irritancy potential and comedogenicity rating against the needs of each skin type — e.g. oily and acne-prone skin are marked down for pore-clogging ingredients, sensitive skin for irritants. A starting heuristic, not a dermatological verdict.

⚠️ Don’t Combine With

📚 Research & Evidence

🔬 The Science

Sodium lauryl sulfate (SLS) is an anionic surfactant—a type of cleaning molecule that helps remove oils and dirt—widely used in consumer products. Here’s what research shows about how it affects your skin and body. #1: Reaction rates and patterns. When SLS is applied to skin in patch testing (a standard allergy test), roughly one-fifth to one-quarter of people show some reaction (Eur J Immunol 2024, Contact Dermatitis 2026). Most of these reactions are weak, appearing as mild redness. Stronger reactions were more common in men, people over 40, and those with occupational or hand dermatitis (Contact Dermatitis 2026). #2: How SLS irritates skin differs from classic allergies.

Interestingly, SLS-induced irritation works through a different biological mechanism than traditional allergic contact dermatitis. In mouse studies, SLS caused less immune cell infiltration and inflammatory signaling compared to classic allergens, but it did trigger pronounced skin cell proliferation (thickening of the outer skin layer) (Eur J Immunol 2024). Both your innate immune system (your body’s first-line defense) and adaptive immune system (which learns to recognize specific threats) are involved in SLS reactions, though a compromised skin barrier alone doesn’t explain the response. #3: Oral effects and mouth ulcers. In the mouth, SLS can cause mucosal desquamation (shedding of the inner lining), irritation, inflammation, and ulcerations (Am J Dent 2022).

For people who suffer from recurrent aphthous ulcers (canker sores), switching to SLS-free toothpaste showed consistent benefits: reduced number of ulcers, shorter healing time, fewer ulcer episodes, and less pain (J Oral Pathol Med 2019). The evidence for this benefit is described as limited but consistent across available studies, though researchers note more rigorous trials are needed (Am J Dent 2022, J Oral Pathol Med 2019). #4: What we still don’t know. The pathophysiological basis—the underlying biological reason—for why SLS triggers reactions in some people remains unclear (Eur J Immunol 2024). Researchers also emphasize that more research is needed on SLS’s effects on the oral and gastrointestinal systems when used in toothpastes (Am J Dent 2022).

Additionally, while SLS can be an indicator of skin irritability for certain high-irritant allergens, it is not a universal marker of sensitivity to all substances (Contact Dermatitis 2026).

📄 Related Research

Matched by search — not necessarily verified support for every statement above.

• Nüsken M et al. (2024). Immune response to topical sodium lauryl sulfate differs from classical irritant and allergic contact dermatitis. Eur J Immunol.
• Kasi SR et al. (2022). Side effects of sodium lauryl sulfate applied in toothpastes: A scoping review. Am J Dent.
• Alli BY et al. (2019). Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: A systematic review. J Oral Pathol Med.
• Piret J et al. (2002). Sodium lauryl sulfate, a microbicide effective against enveloped and nonenveloped viruses. Curr Drug Targets.
• Forkel S et al. (2026). Strengths and Limitations of Sodium Lauryl Sulfate as an Irritant Control in Patch Testing. Contact Dermatitis.

🧴 Products Containing Sodium Lauryl Sulfate

• Blend a med Zahncreme Pro Zahnschmelz
• Oral-B Oral-B 3D White Luxe
• Blend-a-med Complete Expert
• herbal essences champu
• Unilever, Signal Signal Integral 8 Dentifrice Complet 75ml
• H&S Champú
• Oral-B Dentifrice Pro Expert Dents Fortes
• AgeDefy, P&G, Pantène, Pantène Pro-V, Pantène Pro-V Expert, Pantène Pro-V Expert Collection, Procter & Gamble AgeDefy Shampooing
• Head & shoulders 2 in 1 Classic
• Head & Shoulders Shampooing antipelliculaire + après-shampooing 2 in 1 Sensitive
• Procter & gamble as Head&Shoulders Shampoo Classic Clean 400ml
• Colgate
• colgate 6-9 år
• Head & Shoulders Shampooing antipelliculaire + après-shampooing 2 in 1 anti-chute
• h
• Head & Shoulders Shampooing antipelliculaire Instant Relief Apaisement
• Head & Shoulders Shampooing antipelliculaire Instant Apaisement
• Head & Shoulders Shampooing antipelliculaire Lisse & Soyeux (maxi pack)
• Head & Shoulders Shampooing antipelliculaire anti-démangeaisons eucalyptus (maxi pack)
• Head & Shoulders Shampooing antipelliculaire + après-shampooing 2 in 1 Menthol Fresh
• Head & Shoulders Shampooing antipelliculaire Citrus Fresh
• Head & Shoulders Shampooing antipelliculaire Sensitive
• Pantene, Procter & Gamble srl Pantene Pro-V 3 in 1 Shampoo + Balsamo + trattamento
• Blend-a-Med Extra weiss
• Lacura Classic Anti-dandruff Shampoo
• Mentadent Extra Frisch mit Pfefferminz
• Heads and shoulders Smooth and silky heads and shoulders anti dandruff shampoo
• Old Spice Whitewater
• Parogencyl, Procter & Gamble Parogencyl Prévention gencives
• ion Bright White Crème Toner Icy White
• Haleon norway as, Sensodyne Sensodyne Tannkrem Rapid Relief 75ml
• Paradontax Paradontax daily care
• Oral B oral b complete
• Head & Shoulders Men ultra anti-chute
• Parodontax Parodontax Strengthen & Protect Fresh Mint Tandpasta
• Sensodyne Sensodyne Expert Protect Rapide Action
• Herbal Essences bee strong shampoo
• Head & Shoulders, Procter & Gamble Shampooing anti-pelliculaire soin anti-démangeaisons à l’extrait d’eucalyptus
• iWHITE instant teeth whitening
• Shop Line Poudre éclaircissante professionnelle bleue